| Shinseiki Odysselya (1993) | 460,719 | 339 |
| Shinseiki Odysselya 2 (1995) | 13,478 | 67 |
| Shinsekai: Into the Depths (2019) | 2,854,797 | 721 |
| Shinsenden (1989) | 7,690 | 8 |
| Shiny (2016) | 11,044,304 | 1,191 |
| Shiny Ski Resort (2017) | 72,049 | 125 |
| Shinzui Taikyoku Igo: Go Sennin (1995) | 4,743 | 10 |
| Shio (2017) | 642,237 | 257 |
| Shio And Mysterious Forest (2019) | 164 | 10 |
| The Ship (2006) | 73,598,859 | 1,683 |
| Ship Graveyard Simulator (2021) | 21,042,783 | 3,783 |
| Ship Graveyard Simulator 2 (2023) | 9,660,912 | 7,662 |
| Ship It (2016) | 2,389,691 | 181 |
| Ship of Fools (2022) | 3,504,030 | 2,266 |
| Ship of Theseus (2024) | 1,376,705 | 70 |
| Ship Sim 2020 (2020) | 20,065 | 6 |
| Ship Simulator 2006 (2006) | 10,513,184 | 791 |
| Ship Simulator Extremes (2010) | 14,634,278 | 461 |
| Ship Simulator Realistic (2022) | 37,875 | 30 |
| ShipOS 1994 (2024) | 40 | 2 |
| Shipped (2019) | 10,549,908 | 262 |
| Shipping Manager (2023) | 93 | 7 |
| Ships 17 (2016) | 2,252,771 | 62 |
| Ships At Sea (2024) | 3,925,164 | 747 |
| Ships Simulator 2024 (2024) | 14,917 | 8 |
| Ships That Fight Underground (2015) | 281,985 | 64 |
| Shipwreck (2015) | 10,980,271 | 1,174 |
| Shipwreck Escape (2021) | 83,867 | 203 |
| Shipwrecked: Lost Colony (2025) | 0 | 0 |
| Shira Oka: Second Chances (2010) | 209,852 | 27 |
| Shiren the Wanderer (2008) | 3,010,486 | 2,558 |
| Shiren the Wanderer 2 (2000) | 3,322,000 | 2,800 |
| Shiren the Wanderer 4: The Eye of God and the Devil's Navel (2010) | 1,218,581 | 456 |
| Shiren the Wanderer GB2: Magic Castle of the Desert (2001) | 484,207 | 335 |
| Shiren the Wanderer GB: Moonlight Village Monster (1996) | 63,877 | 69 |
| Shiren the Wanderer Side Story: Swordswoman Asuka Arrives! (2002) | 197,405 | 273 |
| Shiren the Wanderer: The Tower of Fortune and the Dice of Fate (2010) | 14,944,160 | 8,668 |
| Shiritsu Justice Gakuen: Nekketsu Seishun Nikki 2 (1999) | 382,076 | 190 |
| Shiro Project:RE (2014) | 5,222,318 | 5,699 |
| Shirogane no Cal to Soukuu no Joou (2010) | 398 | 9 |
| Shiroi Ringu he (1995) | 34,841 | 15 |
| Shirone: the Dragon Girl (2022) | 51,310 | 209 |
| Shisensho Solitaire (2019) | 0 | 0 |
| Shishi : Timeless Prelude (2023) | 10,606 | 53 |
| Shit Game (2008) | 139,001 | 48 |
| The Shivah (2006) | 98,204 | 196 |
| Shiver: Poltergeist (2016) | 94,472 | 152 |
| Shiver: The Lily's Requiem (2018) | 15,941 | 40 |
| Shiver: Vanishing Hitchhiker (2016) | 140,753 | 172 |
| Shivering Hearts (2020) | 8,341 | 16 |
| Shivers (1995) | 1,260,489 | 405 |
| Shivers II: Harvest of Souls (1997) | 79,282 | 244 |
| SHLEMO (2024) | 12 | 1 |
| Shmubedi Boo (2020) | 40,478 | 22 |
| SHMUP Creator (2022) | 26,534 | 172 |
| Shmup Love Boom (2015) | 4,580 | 6 |
| Shmup Moments (2019) | 503 | 3 |
| Shmups Skill Test (2016) | 25,234 | 26 |
| Sho Online (2008) | 115,004 | 12 |
| Shock Troopers (1997) | 2,823,035 | 1,876 |
| Shock Troopers: 2nd Squad (1998) | 1,087,122 | 873 |
| Shock Wave 2: Beyond the Gate (1995) | 37,908 | 29 |
| Shockman (1991) | 401,588 | 537 |
| ShockRods (2019) | 187,081 | 117 |
| Shockwave (1990) | 32,097,921 | 2,329 |
| Shockwave Assault (1994) | 163,150 | 141 |
| SHOCKWAVE TRIGGERS (2025) | 787 | 5 |
| Shockway Rider (1987) | 11,315 | 30 |
| Shoganai (2021) | 2,226 | 5 |
| Shogi 2 (1999) | 899 | 16 |
| Shogi on desk (2018) | 20,708 | 3 |
| Shogo: Mobile Armor Division (1998) | 2,967,850 | 845 |
| Shogun Curse (2024) | 9,264 | 11 |
| Shogun Showdown (2023) | 1,962,926 | 1,522 |
| Shogun Warriors (1992) | 1,629,541 | 216 |
