| Super Robot Wars Z2: Saisei-hen (2012) | 2,355,364 | 292 |
| Super Robot Wars: Original Generations (2007) | 6,689,661 | 5,939 |
| Super Rolling Heroes Deluxe (2024) | 2,186 | 34 |
| Super Rub 'a' Dub (2007) | 120,911 | 118 |
| Super Rude Bear Resurrection (2017) | 197,045 | 272 |
| Super Runabout (2000) | 200,426 | 206 |
| Super Sami Roll (2021) | 372,700 | 437 |
| Super Samurai Rampage (2017) | 4 | 1 |
| Super Sanctum TD (2013) | 0 | 0 |
| Super Saurio Fly (2018) | 572,165 | 22 |
| Super Scope 6 (1992) | 1,643,020 | 397 |
| Super Scrabble (1991) | 41,982 | 46 |
| Super Scramble Simulator (1989) | 13,364 | 32 |
| Super Scribblenauts (2010) | 4,872,426 | 694 |
| Super Seducer (2018) | 49,151,277 | 2,769 |
| Super Seducer 2 (2018) | 45,796,069 | 2,034 |
| Super Sentai Battle: Dice-O (2010) | 45,075 | 8 |
| Super Sentai Legend Wars (2016) | 7,082,231 | 1,090 |
| Super Seymour Saves the Planet (1991) | 7,376 | 16 |
| Super Shanghai 2005 (2004) | 3,699 | 7 |
| Super Shooter (2022) | 663,019 | 199 |
| Super Shot Soccer (2002) | 9,639,590 | 1,329 |
| Super Sidekicks (1992) | 1,319,839 | 933 |
| Super Sidekicks 2: The World Championship (1994) | 1,504,454 | 344 |
| Super Sidekicks 3: The Next Glory (1995) | 0 | 0 |
| Super Silverbrothers (1991) | 200 | 2 |
| Super Skelemania (2017) | 0 | 0 |
| Super Sketch Bob (2023) | 946 | 12 |
| Super Skidmarks (1995) | 136,823 | 113 |
| Super Skramble! (1983) | 1,859 | 4 |
| Super Skull Smash GO! 2 Turbo (2018) | 31,544 | 62 |
| Super Skweek (1990) | 86,367 | 123 |
| Super Sky Arena (2016) | 89,225 | 11 |
| Super Slam Dunk (1993) | 704,824 | 113 |
| Super Slap Shot (1993) | 24,933 | 57 |
| Super Slime Arena (2018) | 1,510,448 | 39 |
| Super Smash Asteroids (2023) | 349 | 11 |
| Super Smash Bros. (1999) | 2,235,712,645 | 137,220 |
| Super Smash Bros. Brawl (2008) | 1,582,062,640 | 143,530 |
| Super Smash Bros. for Nintendo 3DS (2014) | 166,531,071 | 20,714 |
| Super Smash Bros. for Wii U (2014) | 3,744,794,449 | 514,604 |
| Super Smash Bros. Melee (2001) | 1,394,640,815 | 366,026 |
| Super Smash Bros. Ultimate (2018) | 23,250,558,943 | 2,007,985 |
| Super Smash Flash (2006) | 8,588,163 | 1,963 |
| Super Smash Flash 2 (2017) | 90,332,120 | 26,129 |
| Super Smash Land (2011) | 2,161,670 | 314 |
| Super Soccer (1991) | 7,824,220 | 3,179 |
| Super Soccer Blast (2019) | 312,671 | 576 |
| Super Soccer Blast: America vs Europe (2021) | 196,961 | 130 |
| Super Soccer Champ (1992) | 65,605 | 93 |
| Super Sol Standard (2023) | 122 | 5 |
| Super Solitaire (1994) | 13,813 | 107 |
| Super Sonic Racer (2011) | 122,663 | 41 |
| Super Soukoban (1993) | 43,286 | 30 |
| Super Space Club (2021) | 72,248 | 135 |
| Super Space Invaders '91 (1990) | 416,923 | 509 |
| Super Space Jump Man (2019) | 184 | 3 |
| Super Space Meltdown (2015) | 799 | 9 |
| Super Space Pug (2016) | 416 | 10 |
| Super Space Shooter Arena (2019) | 0 | 0 |
| Super Space Slayer 2 (2019) | 19,120 | 387 |
| Super Space Towers (2021) | 362 | 3 |
| Super Spacefortress Macross (1992) | 970,314 | 253 |
| Super Speed Machines (2007) | 1,610 | 11 |
| Super Speed Race (1977) | 576,104 | 57 |
| Super Speed Race V (1978) | 4,915 | 2 |
| Super Spike V'Ball (1989) | 615,742 | 462 |
| Super Spooky Subgame Spectacular (2023) | 110 | 6 |
| Super Sportmatchen (2018) | 973,829 | 66 |
| Super Sprint (1986) | 621,690 | 463 |
| The Super Spy (1990) | 22,498,921 | 459 |
| Super Spy Hunter (1991) | 1,825,359 | 863 |
| Super Spy Hunter (1992) | 129,035 | 79 |
| Super Spy Raccoon (2023) | 3,367 | 30 |
| Super Squad (2021) | 2,068,886 | 236 |
