| Space Saga (2025) | 0 | 0 |
| Space Salvage (2022) | 77,823 | 67 |
| Space Salvager (2014) | 6,508 | 8 |
| Space Scaven (2016) | 2,308 | 4 |
| Space Scavenger (2021) | 3,983,254 | 263 |
| Space Scavenger 2 (2026) | 23,629 | 29 |
| Space Scumbags (2017) | 373,927 | 29 |
| Space Sergeants (2020) | 0 | 0 |
| Space SEX (2021) | 2,870 | 1 |
| Space Shaft (2018) | 98 | 1 |
| Space Shapes (2019) | 2,200 | 4 |
| Space Shells (2022) | 4,048 | 19 |
| The Space Sheriff Spirits (2006) | 369,567 | 272 |
| Space Ship Commander (2017) | 3,100 | 2 |
| Space Ship DRIFT (2021) | 2,308 | 6 |
| Space Ship Infinity (2021) | 14 | 1 |
| Space Shrooms RollPlay (2022) | 0 | 0 |
| Space Shuttle Mission 2007 (2007) | 203,320 | 82 |
| Space Shuttle Project (1991) | 276,921 | 138 |
| Space Shuttle: A Journey into Space (1983) | 27,349 | 49 |
| Space Siege (2008) | 508,404 | 474 |
| Space Simulation Toolkit (2020) | 1,490,491 | 60 |
| Space Slaves (2023) | 7 | 1 |
| Space Slingshot VR (2018) | 995 | 3 |
| Space Slurpies (2021) | 22,304 | 51 |
| Space Smack! (2021) | 61 | 2 |
| Space Spartans (1982) | 46,136 | 27 |
| Space Sprinter VR (2020) | 0 | 0 |
| Space Sprouts (2025) | 2,155 | 17 |
| Space Spy (2009) | 972 | 4 |
| Space Squadron (2020) | 1,298 | 7 |
| Space Squash (1995) | 33,942 | 36 |
| Space Star - Heart of a Soldier (2024) | 1 | 1 |
| Space Station 13 (2003) | 71,416,073 | 9,438 |
| Space Station 51 (2021) | 0 | 0 |
| Space Station Alpha (2015) | 8,489 | 44 |
| Space Station Continuum (2020) | 22,885 | 12 |
| Space Station Defender (2024) | 722 | 3 |
| Space Station Loma: OPERATIONS (2017) | 1,398 | 8 |
| Space Station Manager (2020) | 152,931 | 12 |
| Space Station Sprint (2021) | 26,663 | 56 |
| Space Station Tycoon (2008) | 238,236 | 47 |
| Space Station Tycoon (2020) | 75,819 | 89 |
| Space Station Zulu (1982) | 564 | 2 |
| Space Station: Silicon Valley (1998) | 2,689,225 | 1,420 |
| Space Stories: Darth Star (2018) | 53 | 1 |
| Space Strike (1982) | 61,058 | 93 |
| Space Supermarket Simulator (2026) | 0 | 0 |
| Space Survival (2021) | 3,003,261 | 1,355 |
| Space Survivor (2024) | 1,467,847 | 516 |
| Space Survivors (2025) | 30,607 | 60 |
| Space Tactics (1980) | 12,330 | 20 |
| Space Tail: Every Journey Leads Home (2022) | 183,386 | 352 |
| Space Tail: Lost in the Sands (2022) | 17,090 | 49 |
| Space Tales (2026) | 11,961 | 20 |
| Space Tanks (2006) | 6,701 | 35 |
| Space Taxi (1984) | 201,105 | 175 |
| Space Taxi 2 (2004) | 15,989 | 39 |
| Space Tek (2021) | 25 | 1 |
| Space Theory (2022) | 1,961,286 | 10 |
| Space Thinger (2015) | 3,424 | 6 |
| Space Thugs (2024) | 349 | 2 |
| Space Time Shipyard (2017) | 0 | 0 |
| Space to Grow (2021) | 8,536 | 5 |
| Space Toads Mayhem (2018) | 1,990 | 23 |
| Space Tourist (2025) | 201 | 2 |
| Space Tournament (2025) | 39 | 1 |
| Space Tower Defense (2021) | 9,484 | 84 |
| Space Trade Fleet 1.5 (2019) | 8 | 1 |
| Space Trader (2002) | 6,057 | 46 |
| Space Trader (2007) | 77,682 | 143 |
| Space Trains (2020) | 1,198 | 10 |
| Space Trash Scavenger (2023) | 4,329,025 | 330 |
| Space Travel (1969) | 4,304,718 | 163 |
| Space Travel Idle (2020) | 4,323 | 5 |
