| SPELLHACK!! (2025) | 21,597 | 39 |
| Spelling Challenges and More! (2007) | 15,562 | 16 |
| Spelling Jungle (1993) | 102,092 | 76 |
| Spellinkers (2019) | 879 | 9 |
| Spelljammer: Pirates of Realmspace (1992) | 35,080 | 300 |
| SpellKnights (2016) | 4,323 | 5 |
| Spellmasons (2023) | 267,407 | 65 |
| SpellMaster: The Saga (2021) | 532,179 | 222 |
| Spellpowder: Uprising (2025) | 3,038 | 22 |
| SpellPunk VR (2020) | 462,548 | 41 |
| SpellRogue (2024) | 1,141,375 | 685 |
| Spells & Secrets (2023) | 196,052 | 490 |
| Spells 'n' Stuff (2016) | 0 | 0 |
| Spells and Sacrifice (2024) | 0 | 0 |
| Spells of Gold (2002) | 76,735 | 101 |
| Spellsided (2026) | 28 | 1 |
| Spellslayer (2025) | 608 | 4 |
| Spellstone (2016) | 5,034 | 99 |
| Spellstrife (2024) | 1,493 | 4 |
| Spellsword (2012) | 3,045,755 | 168 |
| Spellsword Cards: DungeonTop (2020) | 43,219 | 59 |
| Spellsworn (2018) | 883,555 | 120 |
| SpellTower (2011) | 36,600 | 30 |
| Spellweaver (2016) | 686,870 | 975 |
| Spelly Cat (2024) | 65 | 6 |
| Spellz: Mastery or Death (2023) | 34 | 1 |
| Spelunker (1983) | 10,903,173 | 2,135 |
| Spelunker Party! (2017) | 1,120,671 | 449 |
| Spelunker World (2015) | 884,604 | 718 |
| Spelunky (2008) | 127,961,437 | 45,285 |
| Spelunky 2 (2020) | 90,654,792 | 45,365 |
| Spelunx (1991) | 14,755 | 9 |
| The Speris Legacy (1996) | 26,263 | 86 |
| Spewer (2009) | 25,056,347 | 127 |
| SPGP Super Polygon Grand Prix (2024) | 1,727 | 13 |
| Sphere - Flying Cities (2022) | 1,216,452 | 400 |
| Sphere 3 (2015) | 349,659 | 114 |
| Sphere Arena (2021) | 14 | 1 |
| Sphere Frustration (2017) | 132 | 4 |
| Sphere game colours (2024) | 0 | 0 |
| Sphere vs Gravity (2024) | 41 | 3 |
| Spherebuddie 64 (2026) | 0 | 0 |
| sphereFACE (2017) | 1,829 | 6 |
| Spheres of Chaos (1992) | 6,932 | 13 |
| Spheria's Familiar (2021) | 3,561 | 3 |
| Spherical (1989) | 949,714 | 165 |
| Spherical Worlds (1996) | 6,940 | 11 |
| Spheriums (2021) | 6,227 | 17 |
| SpHero (2024) | 806,172 | 43 |
| Sphinx and the Cursed Mummy (2003) | 3,976,413 | 2,646 |
| Spice and Wolf VR (2019) | 12,392,921 | 2,538 |
| Spice and Wolf: The Wind that Spans the Sea (2009) | 22,599 | 16 |
| Spice World (1998) | 2,590,715 | 126 |
| Spider and Web (1998) | 1,236 | 12 |
| Spider Fighter (1982) | 10,336,135 | 7,231 |
| Spider Fox (2024) | 567,500 | 105 |
| Spider Solitaire (2020) | 1,291,695 | 797 |
| Spider Solitaire: Black (2018) | 316 | 4 |
| Spider-Man (1982) | 277,822 | 131 |
| Spider-Man (1995) | 1,170,240 | 298 |
| Spider-Man (2000) | 81,053,350 | 12,479 |
| Spider-Man (2002) | 86,601,281 | 7,308 |
| Spider-Man (2018) | 292,775,171 | 134,751 |
| Spider-Man 2 (2004) | 1,721,147,986 | 299,931 |
| Spider-Man 2: Enter Electro (2001) | 19,702,844 | 3,244 |
| Spider-Man 2: The Sinister Six (2001) | 2,054,695 | 155 |
| Spider-Man 3 (2007) | 1,555,797,333 | 27,897 |
| Spider-Man and the X-Men in Arcade's Revenge (1992) | 5,139,270 | 1,019 |
| Spider-Man and Venom: Maximum Carnage (1994) | 14,452,414 | 2,827 |
| Spider-Man Cartoon Maker (1995) | 715,615 | 25 |
| Spider-Man Unlimited (2014) | 252,014,042 | 6,653 |
| Spider-Man vs. The Kingpin (1991) | 10,184,130 | 1,727 |
| Spider-Man: Battle for New York (2006) | 379,626 | 284 |
| Spider-Man: Edge of Time (2011) | 130,498,448 | 5,596 |
| Spider-Man: Far From Home - Virtual Reality Experience (2019) | 154,973,087 | 872 |
