| Spectrewoods (2019) | 417,459 | 475 |
| Spectrobes (2007) | 2,099,214 | 913 |
| Spectrobes: Beyond the Portals (2008) | 746,458 | 423 |
| Spectrobes: Origins (2009) | 5,491,832 | 1,453 |
| Spectrolite (2021) | 7,812 | 62 |
| Spectromancer (2009) | 143,269 | 151 |
| Spectron (1983) | 9,949 | 27 |
| Spectrum (2016) | 911,947 | 195 |
| Spectrum Break (2018) | 0 | 0 |
| The Spectrum Retreat (2018) | 1,471,535 | 2,035 |
| Spectrum Safari (1983) | 818 | 3 |
| Speculum Mortis (2007) | 218 | 2 |
| Speebot (2017) | 3,515 | 24 |
| Speed 3: Grand Prix (2020) | 252,610 | 187 |
| Speed Brawl (2018) | 955,109 | 927 |
| Speed Busters (1998) | 349,444 | 263 |
| Speed Busters: American Highways (1998) | 38,153 | 57 |
| Speed Car Fighter (2018) | 976 | 14 |
| Speed Challenge: Jacques Villeneuve's Racing Vision (2002) | 73,628 | 49 |
| Speed Crew (2024) | 610,054 | 302 |
| Speed Dating for Ghosts (2018) | 9,115,157 | 506 |
| Speed Demons (1999) | 33,415 | 14 |
| Speed Demons (2019) | 6,203 | 26 |
| Speed Freak (1979) | 16,055 | 26 |
| Speed Freaks (1999) | 672,359 | 366 |
| Speed Haste (1995) | 35,482 | 32 |
| Speed is Key (2023) | 1,663,659 | 63 |
| Speed Kills (2014) | 1,098,480 | 157 |
| Speed Kings (2003) | 531,529 | 312 |
| Speed Limit (2021) | 4,064,685 | 660 |
| Speed Mazing (2021) | 1,333 | 12 |
| Speed Power Gunbike (1998) | 132,196 | 76 |
| Speed Race (1974) | 58,374,025 | 1,495 |
| Speed Race Twin (1976) | 23 | 1 |
| Speed Racer (1995) | 5,840,962 | 541 |
| Speed Racer (1996) | 275,751 | 71 |
| Speed Racer in My Most Dangerous Adventures (1994) | 157,583 | 80 |
| Speed Racer in The Challenge of Racer X (1992) | 49,843 | 9 |
| Speed Racer: The Videogame (2008) | 3,265,330 | 4,781 |
| Speed Racing Ultimate (2013) | 108,186 | 94 |
| Speed Rumbler (1986) | 189,743 | 141 |
| Speed Truck Racing (2021) | 8,762 | 44 |
| Speed Witch Battle: White Witch and Five Hopes (2018) | 61,509 | 8 |
| Speed Zone (1988) | 533,648 | 72 |
| Speedball (1988) | 1,784,294 | 317 |
| Speedball 2 Tournament (2007) | 41,674 | 6 |
| Speedball 2100 (2000) | 50,191 | 65 |
| Speedball 2: Brutal Deluxe (1990) | 5,335,382 | 3,345 |
| Speedball 2: Evolution (2011) | 93,339 | 48 |
| Speedboat Assassins (1989) | 2,144 | 10 |
| Speedboat Attack (1997) | 64,816 | 28 |
| Speedboat Raser Europa (2001) | 0 | 0 |
| Speedbreak Hyperdrive (2022) | 814 | 8 |
| Speedollama (2024) | 26,526 | 65 |
| Speedonauts (2023) | 741 | 12 |
| Speedpunk (2021) | 952 | 17 |
| SpeedRunners (2013) | 240,161,834 | 11,386 |
| SpeedRunners (2016) | 28,829,258 | 1,898 |
| SpeedThru: Potzol's Puzzle (2012) | 3,620 | 11 |
| Speedway (1986) | 25,295,340 | 2,421 |
| Speedway Heroes (2020) | 10,019 | 30 |
| Speedway Liga (2009) | 58,474 | 13 |
| Speedway Racing (2020) | 98,138 | 162 |
| Speedway Survival (2024) | 6,488 | 18 |
| Speedx 3D (2010) | 74,470 | 76 |
| Speedy Eggbert (1998) | 214,299 | 293 |
| Speedy Gonzales (1993) | 808,928 | 334 |
| Speedy Gonzales: Aztec Adventure (1999) | 57,649 | 83 |
| Speedy Gonzales: Los Gatos Bandidos (1995) | 1,735,161 | 394 |
| Speedy Gun Savage (2021) | 13,750 | 23 |
| SpeedZone (2009) | 157,820 | 32 |
| Spek. (2019) | 2,551,959 | 108 |
| Spell Beats (2021) | 929 | 4 |
| Spell Bound (1990) | 452,584 | 79 |
| The Spell Brigade (2024) | 2,801,264 | 1,579 |
