| Sengeki Striker (1997) | 39,031 | 57 |
| Sengoku (1991) | 875,500 | 706 |
| Sengoku (2011) | 1,123,686 | 426 |
| Sengoku 2 (1993) | 634,308 | 527 |
| Sengoku 3 (2001) | 1,932,748 | 1,377 |
| Sengoku Basara 2 (2006) | 50,375,357 | 13,763 |
| Sengoku Basara 4 (2014) | 37,311,776 | 11,448 |
| Sengoku Basara X (2008) | 1,931,664 | 429 |
| Sengoku Basara: Samurai Heroes (2010) | 38,323,112 | 8,469 |
| Sengoku Cannon: Sengoku Ace Episode III (2005) | 20,343 | 20 |
| Sengoku Collection (2010) | 853,173 | 61 |
| Sengoku Cyber: Fujimaru Jigokuhen (1995) | 38,008 | 82 |
| Sengoku Dynasty (2023) | 27,734,109 | 12,880 |
| Sengoku Enbu - KIZNA - (2013) | 187,604 | 6,582 |
| Sengoku Genbu (2017) | 10,822 | 3 |
| Sengoku Gensokyo (2007) | 92,811 | 154 |
| Sengoku Jidai: Shadow of the Shogun (2016) | 397,421 | 531 |
| Sengoku Night Blood (2017) | 3,380,605 | 202 |
| Senjyo (1983) | 22,044 | 64 |
| Senko no Ronde 2 (2017) | 164,350 | 433 |
| Senko no Ronde: Dis-United Order (2009) | 314,793 | 147 |
| Senkyu (1995) | 54,955 | 34 |
| Senli 307 (2022) | 90 | 2 |
| Sennen Kazoku (2005) | 4,248,650 | 67 |
| The Senpai (2016) | 90,522,581 | 1,752 |
| Senpai Puzzle: Waifu Summer (2023) | 46 | 2 |
| Senpai Teaches Me Japanese (2019) | 0 | 0 |
| Senran Kagura 2: Deep Crimson (2014) | 1,437,103 | 707 |
| Senran Kagura Burst (2012) | 3,638,373 | 2,126 |
| SENRAN KAGURA Burst Re:Newal (2019) | 2,360,733 | 5,283 |
| Senran Kagura Reflexions (2017) | 2,581,935 | 534 |
| Senran Kagura: Bon Appétit! (2014) | 3,736,510 | 1,565 |
| Senran Kagura: Estival Versus (2015) | 31,829,673 | 20,896 |
| Senran Kagura: Peach Beach Splash (2017) | 6,944,250 | 7,016 |
| Senran Kagura: Shinovi Versus (2013) | 8,868,536 | 3,391 |
| Sense: A Cyberpunk Ghost Story (2020) | 1,214,473 | 946 |
| Sensei! I Like You So Much! (2024) | 6,634 | 50 |
| Sensible Blood Rugby (2021) | 2,850 | 5 |
| Sensible Golf (1994) | 33,707 | 44 |
| Sensible Soccer (1992) | 749,422 | 870 |
| Sensible Soccer '98 (1997) | 23,771 | 18 |
| Sensible Soccer 2006 (2006) | 266,824 | 114 |
| Sensible Soccer 92/93 (1992) | 23,713 | 31 |
| Sensible Soccer: European Champions (1992) | 83,105 | 59 |
| Sensible Train Spotting (1995) | 1,780 | 4 |
| Sensible World of Soccer (1994) | 2,132,504 | 988 |
| Sensible World of Soccer (2007) | 15,117 | 19 |
| Sensible World of Soccer '96/'97 (1996) | 299,322 | 432 |
| Sensorium Galaxy (2023) | 15,528 | 12 |
| Sensual Haunting (2022) | 22,758 | 6 |
| Sentenced VR (2021) | 836,657 | 41 |
| Sentience (2021) | 2,135,530 | 235 |
| Sentience: The Android's Tale (2017) | 0 | 0 |
| Sentient (1997) | 9,942,517 | 402 |
| The Sentient Box (2022) | 3,215 | 33 |
| SENTIENT STEEL (2024) | 553 | 7 |
| Sentimental Graffiti (1998) | 426,156 | 120 |
| Sentimental Graffiti 2 (2000) | 49,155 | 20 |
| Sentimental K (2022) | 37,020 | 96 |
| Sentimental Trickster: Yaoi BL Gay Visual Novel (2021) | 8,907 | 2 |
| Sentinel (1984) | 4,979 | 7 |
| The Sentinel (1986) | 11,960,540 | 2,507 |
| Sentinel (2600) | 4,841 | 16 |
| Sentinel Point Heroes (2025) | 89 | 5 |
| Sentinel Returns (1998) | 92,229 | 76 |
| Sentinel Worlds I: Future Magic (1988) | 38,086 | 75 |
| Sentinel: Cursed Knight (2021) | 21,626 | 16 |
| Sentinel: Descendants in Time (2004) | 92,692 | 85 |
| Sentinels of Earth-Prime (2023) | 3,869 | 27 |
| Sentinels of Freedom (2020) | 86,763 | 98 |
| Sentinels of the Multiverse: The Video Game (2014) | 864,835 | 1,171 |
| Sentou Danchi (2013) | 11,070 | 2 |
| Sentou Gakuen: Revival (2025) | 47 | 3 |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (2003) | 18,271 | 7 |
| Sentris (2014) | 89,259 | 54 |
