| Slime 3K: Rise Against Despot (2023) | 1,278,647 | 497 |
| Slime Brawly Brawl (2024) | 0 | 0 |
| Slime CCG (2018) | 27,745 | 22 |
| Slime Clicker (2025) | 233 | 6 |
| Slime Climber (2024) | 0 | 0 |
| Slime Dungeon (2022) | 8,733 | 27 |
| Slime Fantasy: the search for the lost sword (2021) | 0 | 0 |
| Slime Girl Smoothies (2022) | 31,398 | 26 |
| Slime Heroes (2023) | 73,151 | 206 |
| Slime Kingdom - An Unlikely Adventure! (2021) | 3,484 | 33 |
| Slime Masters (2024) | 24,981 | 36 |
| Slime Mayhem (2024) | 27 | 2 |
| Slime Mori Mori Dragon Quest 3 (2011) | 482,623 | 116 |
| Slime Princess (2025) | 22,612 | 1 |
| Slime Rancher (2016) | 1,871,982,567 | 107,027 |
| Slime Rancher 2 (2022) | 125,153,788 | 35,276 |
| Slime Research (2019) | 177 | 3 |
| Slime Scramble (2024) | 11,473 | 10 |
| Slime Siege (2024) | 39,837 | 22 |
| Slime Slam (2019) | 10 | 1 |
| Slime Tactics (2019) | 31,532 | 13 |
| Slime Wars (2024) | 296,232 | 14 |
| Slime-san (2017) | 530,698 | 573 |
| Slime-san: Blackbird's Kraken (2017) | 3,769 | 9 |
| Slime-san: Creator (2018) | 2,499 | 3 |
| Slime-san: Sheeple's Sequel (2018) | 6,449 | 6 |
| Slime: The Cleaner (2025) | 0 | 0 |
| The Slimeking's Tower (2017) | 114,683 | 105 |
| Slimes & Dusters TO (2024) | 0 | 0 |
| Slimes - Cannon Combat (2023) | 0 | 0 |
| Slimes are the Strongest (2024) | 0 | 0 |
| Slimesventure: Your Destination (2022) | 0 | 0 |
| Slimy Sextet (2023) | 23,199 | 17 |
| Sling Drift (2018) | 3,323,452 | 487 |
| Sling Kong (2015) | 1,373,170 | 211 |
| Sling Ming (2018) | 18,013 | 46 |
| Sling-A-Thing (2025) | 1,839 | 23 |
| Slingo (1998) | 132,478 | 67 |
| Slingo Quest (2006) | 21,289 | 18 |
| Slingo Quest Hawaii (2008) | 2,051 | 4 |
| SlingStar (2022) | 62 | 6 |
| Slinki (2014) | 3,156 | 11 |
| Slinky (1983) | 10,975,017 | 181 |
| Slip 'n Dip (2020) | 44 | 2 |
| Slipgate (2025) | 110,154 | 452 |
| SlipSlop: World's Hardest Platformer Game (2019) | 486 | 8 |
| Slipstream 5000 (1995) | 296,862 | 90 |
| Sliptime Sleuth (2020) | 738 | 6 |
| Slipways (2021) | 1,336,764 | 851 |
| Slither (1982) | 80,645,419 | 1,515 |
| Slither Loop (2020) | 435 | 3 |
| Slither.io (2016) | 7,458,842,991 | 61,871 |
| Slitherise (2025) | 0 | 0 |
| Slizer Battle Management System (2018) | 2,098 | 5 |
| Slo's Home (2024) | 1,171 | 2 |
| Slobbish Dragon Princess (2021) | 33,064 | 130 |
| Slobbish Dragon Princess 2 (2021) | 6,454 | 32 |
| Slopecrashers (2023) | 150,047 | 207 |
| Sloppy Forgeries (2019) | 155 | 1 |
| Slordax: The Unknown Enemy (1991) | 5,210 | 15 |
| The Slormancer (2021) | 2,545,589 | 2,225 |
| Slot & Dungeons (2025) | 136,605 | 192 |
| Slot Car Rivals (2016) | 36,694 | 38 |
| Slot Gambler (1995) | 238 | 3 |
| Slot Machine (1979) | 76,875,182 | 4,626 |
| Slot Racers (1978) | 67,459 | 71 |
| Slot Shots Pinball Collection (2022) | 15,195 | 91 |
| Sloth Tales (2020) | 85 | 5 |
| Sloth: Heart to Heart (2019) | 1,320 | 5 |
| The Slothgate Experiment (2022) | 53,767 | 16 |
| Slotomania (2011) | 3,504,319 | 3,170 |
| Slotz Racer (2009) | 76,386 | 12 |
| Slow Down, Bull (2015) | 11,084 | 37 |
| Sludge Fighters (2021) | 23 | 1 |
| Sludge Life (2020) | 2,991,815 | 1,154 |
