| Selaco (2255) | 1,631,334 | 811 |
| Selatria (2022) | 3,271 | 11 |
| Selene ~Apoptosis~ (2023) | 398,345 | 395 |
| Selene's Unbearable Night (2023) | 218,943 | 273 |
| Seleniak (2004) | 502 | 6 |
| Selenon Rising (2016) | 48,429 | 5 |
| Selenwald (2025) | 1,413 | 5 |
| Self Defense Kinda... (2024) | 44 | 3 |
| Self-Checkout Unlimited (2020) | 125,118 | 50 |
| Self-Defense Training Camp (2011) | 86,851 | 17 |
| Self-Delusion (2022) | 1,517,811 | 295 |
| Selfie Girls (2023) | 7,289 | 6 |
| Selfloss (2024) | 148,187 | 378 |
| Selfy Collection (2020) | 60,265 | 75 |
| SELINI (2026) | 21,514 | 78 |
| Sellardore Tales (2002) | 0 | 0 |
| Sellsword Saga (2024) | 0 | 0 |
| Sellsword Tales (2026) | 0 | 0 |
| Sellswords: Ashen Company (2019) | 747,466 | 46 |
| Selma and the Wisp (2016) | 180,628 | 244 |
| Selobus Fantasy (2022) | 9,364 | 8 |
| Semblance (2018) | 1,854,226 | 382 |
| Semispheres (2017) | 23,382 | 81 |
| Sempiternal The Backrooms (2023) | 0 | 0 |
| Sempra Infernalis (2024) | 0 | 0 |
| Sen no Kaizoku (2015) | 84,725 | 10 |
| Senalux (2017) | 1,709 | 37 |
| Seneca 7: A Cyberpunk Odyssey (2024) | 1 | 1 |
| Senet (2022) | 17,455 | 29 |
| The Senex Bird (2023) | 1,616 | 26 |
| Sengeki Striker (1997) | 56,816 | 65 |
| Sengoku (1991) | 876,593 | 721 |
| Sengoku (2011) | 1,173,398 | 452 |
| Sengoku 2 (1993) | 653,445 | 555 |
| Sengoku 3 (2001) | 1,941,987 | 1,444 |
| Sengoku Basara 2 (2006) | 52,194,784 | 14,602 |
| Sengoku Basara 4 (2014) | 37,308,451 | 11,655 |
| Sengoku Basara X (2008) | 1,933,423 | 440 |
| Sengoku Basara: Samurai Heroes (2010) | 38,405,879 | 8,626 |
| Sengoku Cannon: Sengoku Ace Episode III (2005) | 20,347 | 21 |
| Sengoku Collection (2010) | 853,177 | 61 |
| Sengoku Cyber: Fujimaru Jigokuhen (1995) | 38,320 | 89 |
| Sengoku Dynasty (2023) | 29,338,266 | 15,279 |
| Sengoku Enbu - KIZNA - (2013) | 187,632 | 6,583 |
| Sengoku Genbu (2017) | 10,822 | 3 |
| Sengoku Gensokyo (2007) | 93,068 | 175 |
| Sengoku Jidai: Shadow of the Shogun (2016) | 397,621 | 532 |
| Sengoku Night Blood (2017) | 3,393,224 | 204 |
| Senjyo (1983) | 22,044 | 65 |
| Senko no Ronde 2 (2017) | 164,708 | 435 |
| Senko no Ronde: Dis-United Order (2009) | 316,598 | 147 |
| Senkyu (1995) | 57,407 | 36 |
| Senli 307 (2022) | 90 | 2 |
| Sennen Kazoku (2005) | 4,248,667 | 67 |
| The Senpai (2016) | 91,304,217 | 1,779 |
| Senpai Puzzle: Waifu Summer (2023) | 46 | 2 |
| Senpai Teaches Me Japanese (2019) | 0 | 0 |
| Senran Kagura 2: Deep Crimson (2014) | 1,438,680 | 713 |
| Senran Kagura Burst (2012) | 3,646,468 | 2,161 |
| SENRAN KAGURA Burst Re:Newal (2019) | 2,364,920 | 5,328 |
| Senran Kagura Reflexions (2017) | 2,583,213 | 560 |
| Senran Kagura: Bon Appétit! (2014) | 3,738,901 | 1,713 |
| Senran Kagura: Estival Versus (2015) | 31,865,204 | 21,250 |
| Senran Kagura: Peach Beach Splash (2017) | 6,967,710 | 7,083 |
| Senran Kagura: Shinovi Versus (2013) | 8,871,624 | 3,412 |
| Sense of The Devil (2017) | 0 | 0 |
| Sense: A Cyberpunk Ghost Story (2020) | 1,218,748 | 957 |
| Sensei! I Like You So Much! (2024) | 7,082 | 57 |
| Sensible Blood Rugby (2021) | 2,850 | 5 |
| Sensible Golf (1994) | 35,999 | 46 |
| Sensible Soccer (1992) | 766,052 | 906 |
| Sensible Soccer '98 (1997) | 23,771 | 18 |
| Sensible Soccer 2006 (2006) | 269,973 | 116 |
| Sensible Soccer 92/93 (1992) | 24,244 | 32 |
| Sensible Soccer: European Champions (1992) | 83,820 | 61 |
