| Sense: A Cyberpunk Ghost Story (2020) | 1,220,370 | 957 |
| Sensei! I Like You So Much! (2024) | 7,082 | 57 |
| Sensible Blood Rugby (2021) | 2,850 | 5 |
| Sensible Golf (1994) | 35,999 | 46 |
| Sensible Soccer (1992) | 766,052 | 906 |
| Sensible Soccer '98 (1997) | 23,771 | 18 |
| Sensible Soccer 2006 (2006) | 269,973 | 116 |
| Sensible Soccer 92/93 (1992) | 24,244 | 32 |
| Sensible Soccer: European Champions (1992) | 83,820 | 61 |
| Sensible Train Spotting (1995) | 3,008 | 5 |
| Sensible World of Soccer (1994) | 2,146,912 | 1,000 |
| Sensible World of Soccer (2007) | 15,117 | 19 |
| Sensible World of Soccer '96/'97 (1996) | 315,613 | 455 |
| Sensorium Galaxy (2023) | 15,528 | 12 |
| Sensual Adventures - Treasure Island (2025) | 0 | 0 |
| Sensual Haunting (2022) | 22,758 | 6 |
| Sentenced VR (2021) | 836,660 | 41 |
| Sentience (2021) | 2,136,775 | 238 |
| Sentience: The Android's Tale (2017) | 3,083 | 11 |
| Sentient (1997) | 9,964,017 | 412 |
| The Sentient Box (2022) | 3,215 | 33 |
| SENTIENT STEEL (2024) | 553 | 7 |
| Sentimental Graffiti (1998) | 426,169 | 121 |
| Sentimental Graffiti 2 (2000) | 49,155 | 20 |
| Sentimental K (2022) | 37,148 | 97 |
| Sentimental Trickster: Yaoi BL Gay Visual Novel (2021) | 8,907 | 2 |
| Sentinel (1984) | 4,979 | 7 |
| The Sentinel (1986) | 14,207,609 | 2,784 |
| Sentinel (2600) | 4,841 | 16 |
| Sentinel Agency (2024) | 0 | 0 |
| Sentinel Point Heroes (2025) | 89 | 5 |
| Sentinel Returns (1998) | 93,278 | 79 |
| Sentinel Signal (2025) | 0 | 0 |
| Sentinel Worlds I: Future Magic (1988) | 38,086 | 75 |
| Sentinel: Cursed Knight (2021) | 21,626 | 16 |
| Sentinel: Descendants in Time (2004) | 92,758 | 86 |
| Sentinels of Earth-Prime (2023) | 3,882 | 28 |
| Sentinels of Freedom (2020) | 87,990 | 100 |
| Sentinels of the Multiverse: The Video Game (2014) | 872,054 | 1,203 |
| Sentou Danchi (2013) | 11,070 | 2 |
| Sentou Gakuen: Revival (2025) | 47 | 3 |
| Sentou Yousei Yukikaze: Yousei no Mau Sora (2003) | 18,271 | 7 |
| Sentris (2014) | 89,259 | 54 |
| Sentry (2020) | 25,587,054 | 632 |
| Sentry City (2022) | 33,358 | 55 |
| Sentry Knight Tactics (2016) | 70,638 | 73 |
| Senua's Saga: Hellblade II (2023) | 68,111,223 | 36,713 |
| Seonbi : Scholar of Joseon (2023) | 3,932 | 10 |
| Sep's Diner (2020) | 34,795 | 62 |
| Separated (2026) | 0 | 0 |
| Separation (2020) | 19,277 | 29 |
| Sephiria (2025) | 242,157 | 166 |
| Sephonie (2021) | 177,503 | 481 |
| Sepia Tears (2016) | 19,311 | 232 |
| Septaroad Voyager (2023) | 9,011 | 82 |
| SEPTEMBER 1999 (2018) | 4,374,189 | 750 |
| Septerra Core: Legacy of the Creator (1999) | 1,489,743 | 3,544 |
| Septic Savages (2016) | 0 | 0 |
| Septipus: Tentacle Apocalypse (2012) | 2,755 | 1 |
| Sepulchron (2025) | 45 | 1 |
| Sepulcrum (2025) | 0 | 0 |
| SEQUENCE STORM (2018) | 9,004 | 66 |
| Serafina's Crown (2016) | 7,696 | 4 |
| Serafina's Saga: Awakened (2024) | 16,229 | 27 |
| Seraph (2016) | 3,402,810 | 741 |
| Seraph of the End: Bloody Blades (2015) | 207,209 | 36 |
| Seraph of the End: The Origin of Fate (2015) | 10,954 | 4 |
| Seraph's Last Stand (2022) | 5,475,996 | 538 |
| Seraphic Destroyer (2019) | 14,569 | 6 |
| Seraphim Slum (2024) | 665 | 5 |
| Serega Madness Pixel Adventures (2024) | 0 | 0 |
| Serena (2014) | 7,586,904 | 580 |
| Serenade of the Sirens (2018) | 177 | 5 |
| Serendia - Random Equip Draw Defense (2025) | 0 | 0 |
| Serendipity Hotel (2022) | 51 | 3 |
