| Serious Sam HD: The First Encounter (2010) | 5,528,179 | 5,823 |
| Serious Sam HD: The Second Encounter (2010) | 8,335,324 | 5,424 |
| Serious Sam VR: The Last Hope (2017) | 3,884,666 | 540 |
| Serious Sam's Bogus Detour (2017) | 0 | 0 |
| Serious Sam: I Hate Running Backwards (2018) | 429,936 | 207 |
| Serious Sam: Kamikaze Attack! (2011) | 580,700 | 133 |
| Serious Sam: Next Encounter (2004) | 1,706,174 | 1,560 |
| Serious Sam: Siberian Mayhem (2022) | 11,056,340 | 8,067 |
| Serious Sam: The First Encounter (2001) | 14,999,282 | 10,643 |
| Serious Sam: The Greek Encounter (2012) | 31,229 | 17 |
| Serious Sam: The Random Encounter (2011) | 1,222,039 | 153 |
| Serious Sam: The Second Encounter (2002) | 17,294,018 | 13,925 |
| Serious Sam: Tormental (2019) | 817,627 | 188 |
| Serious Sam: Tormental (2022) | 142,384 | 164 |
| Serious Scramblers (2018) | 6,198 | 50 |
| Serke (2024) | 93 | 8 |
| Serment - Contract with a Devil (2019) | 13,248 | 64 |
| Serpent (1990) | 53,604 | 39 |
| Serpent in the Staglands (2015) | 258,891 | 243 |
| The Serpent of Isis (2009) | 140,113 | 35 |
| The Serpent Rogue (2022) | 1,703,395 | 728 |
| Serpent Showdown (2021) | 10 | 2 |
| The Serpent's Star (1983) | 37,395 | 11 |
| Serpentine (1982) | 5,730,374 | 266 |
| Serum (2024) | 5,261,247 | 1,470 |
| Servants of Sumomon (2023) | 0 | 0 |
| ServiceIT: You can do IT (2024) | 72,171 | 174 |
| Servonauts (2024) | 18,479 | 52 |
| Sesame Street Elmo's Preschool (1996) | 2,520,901 | 145 |
| Sesame Street Sports (2001) | 455,952 | 132 |
| Sesame Street: 123 (1989) | 457,979 | 93 |
| Sesame Street: A-B-C (1989) | 349,012 | 160 |
| Sesame Street: Big Bird's Hide and Speak (1990) | 115,315 | 103 |
| Sesame Street: Cookie's Counting Carnival (2010) | 409,762 | 95 |
| Sesame Street: Countdown (1992) | 1,086,545 | 150 |
| Sesame Street: Counting Cafe (1994) | 103,325 | 70 |
| Sesame Street: Elmo's A-to-Zoo Adventure (2010) | 178,677 | 85 |
| Sesame Street: Elmo's Musical Monsterpiece (2012) | 383,874 | 61 |
| Sesame Street: Letter-Go-Round (1984) | 15,072 | 18 |
| Sesame Street: Numbers (1991) | 251,217 | 51 |
| Sesame Street: Once Upon a Monster (2011) | 1,958,917 | 288 |
| Sesame Street: Ready, Set, Grover! (2011) | 524,042 | 110 |
| Sesame Street: The Adventures of Elmo in Grouchland (1999) | 1,083,568 | 87 |
| Session Seven (2019) | 13,472 | 63 |
| Session: Skate Sim (2022) | 32,062,904 | 18,206 |
| Set Sail! Arena (2024) | 0 | 0 |
| Set Yourself on Fire (2026) | 38 | 1 |
| Setr's Auto Battler (2021) | 5,397 | 12 |
| Settlement Survival (2021) | 30,091,442 | 5,598 |
| Settlement: Colossus (2010) | 16,631 | 44 |
| Settlements Rising (2024) | 394,631 | 270 |
| Settlemoon (2023) | 646 | 25 |
| Settler's Odyssey (2023) | 0 | 0 |
| The Settlers (1993) | 10,612,373 | 3,676 |
| The Settlers (2019) | 77,039 | 12 |
| The Settlers (2022) | 271,780 | 105 |
| The Settlers 7: Paths to a Kingdom (2010) | 23,384,223 | 2,757 |
| The Settlers II (1996) | 7,621,822 | 6,863 |
| The Settlers III (1998) | 7,245,973 | 6,583 |
| The Settlers IV (2001) | 9,293,338 | 5,235 |
| The Settlers Online (2011) | 8,911,309 | 863 |
| The Settlers: Heritage of Kings (2004) | 6,082,692 | 7,359 |
| The Settlers: New Allies (2024) | 5,237,028 | 2,576 |
| The Settlers: Rise of an Empire (2007) | 4,002,923 | 4,392 |
| The Settlers: Rise of Cultures (2008) | 8,939 | 20 |
| The Settlers: Smack a Thief! (2000) | 8,142 | 4 |
| The Settlings (2024) | 2,105,303 | 223 |
| SEUM: Speedrunners from Hell (2016) | 15,722,671 | 1,263 |
| The Seven Chambers (2018) | 43,853 | 76 |
| The Seven Cities of Gold (1984) | 102,031 | 75 |
| Seven Days (2017) | 751,927 | 363 |
| Seven days with the Ghost (2018) | 14,151 | 7 |
| Seven Deadly Dates (2022) | 88,663 | 31 |
| The Seven Deadly Seas (2019) | 78,724 | 25 |
| The Seven Deadly Sins (2020) | 461,216,707 | 28,859 |
