| Sesame Street: Big Bird's Hide and Speak (1990) | 111,858 | 93 |
| Sesame Street: Cookie's Counting Carnival (2010) | 404,772 | 90 |
| Sesame Street: Countdown (1992) | 1,085,366 | 143 |
| Sesame Street: Counting Cafe (1994) | 101,640 | 65 |
| Sesame Street: Elmo's A-to-Zoo Adventure (2010) | 174,787 | 79 |
| Sesame Street: Elmo's Musical Monsterpiece (2012) | 383,709 | 58 |
| Sesame Street: Letter-Go-Round (1984) | 15,072 | 17 |
| Sesame Street: Numbers (1991) | 251,147 | 50 |
| Sesame Street: Once Upon a Monster (2011) | 1,958,670 | 287 |
| Sesame Street: Ready, Set, Grover! (2011) | 523,138 | 90 |
| Sesame Street: The Adventures of Elmo in Grouchland (1999) | 1,082,671 | 81 |
| Session Seven (2019) | 13,472 | 63 |
| Session: Skate Sim (2022) | 30,684,416 | 16,899 |
| Set Sail! Arena (2024) | 0 | 0 |
| Setr's Auto Battler (2021) | 5,363 | 12 |
| Settlement Survival (2021) | 29,706,971 | 5,396 |
| Settlement: Colossus (2010) | 16,628 | 44 |
| Settlements Rising (2024) | 386,890 | 242 |
| Settlemoon (2023) | 643 | 24 |
| Settler's Odyssey (2023) | 0 | 0 |
| The Settlers (1993) | 10,603,145 | 3,653 |
| The Settlers (2019) | 77,039 | 12 |
| The Settlers (2022) | 271,775 | 105 |
| The Settlers 7: Paths to a Kingdom (2010) | 23,373,177 | 2,744 |
| The Settlers II (1996) | 7,504,602 | 6,644 |
| The Settlers III (1998) | 7,202,777 | 6,255 |
| The Settlers IV (2001) | 9,216,758 | 4,879 |
| The Settlers Online (2011) | 8,911,027 | 861 |
| The Settlers: Heritage of Kings (2004) | 6,070,423 | 7,261 |
| The Settlers: New Allies (2024) | 5,215,195 | 2,489 |
| The Settlers: Rise of an Empire (2007) | 4,000,253 | 4,330 |
| The Settlers: Rise of Cultures (2008) | 8,323 | 20 |
| The Settlers: Smack a Thief! (2000) | 8,142 | 4 |
| The Settlings (2024) | 2,071,793 | 211 |
| SEUM: Speedrunners from Hell (2016) | 15,720,789 | 1,250 |
| The Seven Chambers (2018) | 43,554 | 71 |
| The Seven Cities of Gold (1984) | 0 | 0 |
| Seven Days (2017) | 569,927 | 345 |
| Seven days with the Ghost (2018) | 14,137 | 7 |
| Seven Deadly Dates (2022) | 88,663 | 31 |
| The Seven Deadly Seas (2019) | 78,724 | 25 |
| The Seven Deadly Sins (2020) | 443,683,364 | 20,696 |
| The Seven Deadly Sins: Grand Cross (2020) | 850,861,551 | 111,393 |
| The Seven Deadly Sins: Knights of Britannia (2018) | 28,120,349 | 4,186 |
| Seven Deadly Sins: Unjust Sin (2015) | 62,865 | 60 |
| Seven Doors (2020) | 240,349 | 313 |
| The Seven Gates of Jambala (1989) | 54,639 | 59 |
| Seven Kingdoms (1997) | 12,183,570 | 743 |
| Seven Kingdoms II: The Fryhtan Wars (1999) | 259,251 | 237 |
| Seven Kingdoms: Conquest (2008) | 140,697 | 59 |
| Seven Knights (2015) | 392,431,796 | 31,116 |
| Seven Knights 2 (2020) | 93,813,287 | 25,203 |
| Seven Lovers In The House (2024) | 982 | 8 |
| The Seven Realms - Realm 1 (2022) | 0 | 0 |
| The Seven Realms: High Lathión (2024) | 4,351 | 7 |
| Seven Samurai 20XX (2004) | 227,338 | 175 |
| Seven Seas Deluxe (2001) | 0 | 0 |
| Seven Skies to Paradise (2024) | 481 | 10 |
| The Seven Spirits of Ra (1987) | 1,637 | 4 |
| Seven Wonders of St. Clementine (2020) | 411 | 7 |
| The Seven Years War (1756-1763) (2015) | 11,938 | 6 |
| Seven: Molmorth no Kiheitai (2000) | 114,048 | 271 |
| Seven: The Days Long Gone (2017) | 2,543,885 | 1,450 |
| Seventh Angel (2022) | 35,150 | 20 |
| Seventh Cross: Evolution (1998) | 115,319 | 115 |
| Seventh Fleet (1985) | 2 | 1 |
| Seventh Lair (2022) | 58,617 | 68 |
| The Several Journeys of Reemus: Chapter 1 - The Royal Journey (2008) | 2,140,596 | 41 |
| Severance: Blade of Darkness (2001) | 8,316,434 | 3,309 |
| Severed (2016) | 2,060,992 | 383 |
| Severed Steel (2021) | 3,319,471 | 3,527 |
| Sewer Sam (1983) | 14,195 | 24 |
| Sewer Shark (1992) | 780,316 | 244 |
| Sewing Machine Simulator (2024) | 705 | 1 |
| Sex Adventures - Kinky Bondage (2022) | 0 | 0 |
