| Shuushoku Game (1995) | 0 | 0 |
| Shuyaku Sentai Irem Fighter (1993) | 4,273 | 6 |
| Shuyan Saga (2017) | 270,181 | 251 |
| Shy Cats Hidden Orchestra (2023) | 5,463 | 44 |
| Siana Tales (2023) | 238 | 4 |
| Siberian Dawn (2018) | 125 | 1 |
| Siberian Strike (2009) | 73,123 | 78 |
| Sid Meier's Alien Crossfire (1999) | 731,892 | 252 |
| Sid Meier's Alpha Centauri (1999) | 7,583,602 | 882 |
| Sid Meier's Antietam! (1999) | 22,098 | 5 |
| Sid Meier's Colonization (1994) | 2,793,779 | 1,272 |
| Sid Meier's Covert Action (1990) | 295,948 | 258 |
| Sid Meier's Gettysburg! (1997) | 314,017 | 51 |
| Sid Meier's Pirates! (1987) | 537,249 | 234 |
| Sid Meier's Pirates! (2004) | 21,783,786 | 3,833 |
| Sid Meier's Railroad Tycoon Deluxe (1993) | 7,711 | 12 |
| Sid Meier's Railroads! (2006) | 2,529,458 | 860 |
| Sid Meier's SimGolf (2002) | 409,792 | 228 |
| Sid Meier's Starships (2015) | 4,356,782 | 496 |
| Side B (2021) | 149,968 | 124 |
| Side by Side (1996) | 173,075,026 | 1,144 |
| Side by Side 2 Evoluzione (1997) | 96,769 | 49 |
| Side by Side Special (1997) | 328,785 | 236 |
| Side Effect (2022) | 295,422 | 167 |
| Side Pocket (1986) | 1,588,933 | 1,064 |
| Side Pocket 3 (1997) | 10,801 | 24 |
| Sidereal Wanderer (2024) | 32 | 2 |
| SideShow (1989) | 35,241,287 | 2,417 |
| Sidestep Legends (2023) | 10,845 | 19 |
| Sideswiped (2009) | 56,658,336 | 43 |
| Sidewalk (1987) | 39,126,176 | 291 |
| Sideway: New York (2011) | 568,875 | 147 |
| Sidewinder (1988) | 5,660,768 | 778 |
| Sidewize (1987) | 5,429 | 11 |
| Siebenstreich (2021) | 51,601 | 32 |
| Siege (1992) | 44,179,262 | 6,857 |
| Siege Hero (2011) | 2,452,097 | 400 |
| Siege of Avalon (2000) | 251,517 | 507 |
| The Siege of Brimir (2022) | 2,898 | 7 |
| Siege of Centauri (2019) | 443,575 | 200 |
| Siege of Dungeon (2023) | 595,687 | 113 |
| Siege of Treboulain (2022) | 1,417 | 2 |
| Siege Saga (2018) | 2,280,980 | 38 |
| Siege Survival: Gloria Victis (2021) | 13,395,598 | 2,579 |
| Siege the Day (2021) | 385,206 | 110 |
| Siege Up! (2023) | 1,166,606 | 473 |
| Siege: Titan Wars (2017) | 1,951,865 | 79 |
| Siegecraft Commander (2017) | 706,657 | 209 |
| Sierra Championship Boxing (1983) | 7,355 | 14 |
| Sierra's 3-D Helicopter Simulator (1987) | 2,562 | 8 |
| Sift Heads Cartels (2024) | 0 | 0 |
| Sifu (2022) | 215,457,255 | 66,578 |
| Sigformation (2023) | 0 | 0 |
| Sigil (2019) | 1,950,107 | 1,384 |
| Sigil of the Magi (2022) | 165,449 | 97 |
| Sigils Of Elohim (2014) | 75,838 | 185 |
| Sigma 7 (1986) | 19,776 | 27 |
| Sigma Draconis (2021) | 9,761 | 6 |
| Sigma Harmonics (2008) | 71,090 | 27 |
| Sigma Impact (2021) | 17,717 | 8 |
| Sigma Star Saga (2005) | 283,406 | 248 |
| Sigma Theory: Global Cold War (2019) | 1,424,779 | 663 |
| Sign Motion (2014) | 1,052,452 | 37 |
| Sign of Silence (2020) | 56,243,348 | 1,662 |
| The Signal From Tölva (2017) | 877,624 | 637 |
| The Signal State (2021) | 155,798 | 183 |
| Signalis (2022) | 708,941 | 300 |
| Signed and Sealed With a Kiss (2019) | 61,041 | 20 |
| Signs of the Sojourner (2020) | 116,776 | 279 |
| Signum Perfectum (2022) | 19 | 4 |
| Signus: The Artifact Wars (1998) | 752 | 1 |
| Siheyuan (2023) | 132 | 13 |
| SIK Space Invader Kreature (2021) | 0 | 1 |
| Sikaq (2018) | 11 | 2 |
| Silas (2010) | 8,894,766 | 678 |
