| Sparta: War of Empires (2014) | 2,738,174 | 120 |
| Spartacus Legends (2013) | 8,331,234 | 880 |
| Spartan (2004) | 30,848,882 | 1,858 |
| Spartan Fist (2018) | 217,932 | 91 |
| Spartan X 2 (1991) | 295,685 | 334 |
| Spartan: Total Warrior (2005) | 11,625,614 | 2,692 |
| SPASE DEFENSE (2024) | 0 | 0 |
| Spasim (1974) | 346,897 | 11 |
| SpatialErotica (2025) | 0 | 0 |
| The Spatials (2015) | 3,956,828 | 1,073 |
| The Spatials: Galactology (2018) | 198,621 | 213 |
| Spawn (1999) | 59,600,115 | 3,431 |
| Spawn Kings (2021) | 5,417 | 12 |
| Spawn: Armageddon (2003) | 4,725,992 | 1,232 |
| Spawn: In the Demon's Hand (2000) | 1,031,933 | 538 |
| Spawn: The Eternal (1997) | 1,043,802 | 260 |
| Speaking Simulator (2019) | 30,866,340 | 437 |
| Spear Leap Saga (2024) | 1 | 2 |
| Spear Master (2020) | 101,561 | 64 |
| Spear of Destiny (1992) | 5,958,649 | 3,543 |
| Spear Resurrection (2001) | 483,213 | 204 |
| Spear Song (2024) | 15,918 | 68 |
| Speard (2023) | 2 | 1 |
| Spearhead (1998) | 1,561,042 | 298 |
| SpearHeads (2023) | 731 | 9 |
| Spears 'n' Spades (2017) | 0 | 0 |
| Spec Ops II: Green Berets (1999) | 339,386 | 131 |
| Spec Ops: Airborne Commando (2002) | 92,221 | 82 |
| Spec Ops: Covert Assault (2001) | 108,234 | 126 |
| Spec Ops: Ranger Elite (2001) | 330,568 | 191 |
| Spec Ops: Rangers Lead the Way (1998) | 361,460 | 59 |
| Spec Ops: Stealth Patrol (2000) | 374,663 | 163 |
| Spec Ops: The Line (2012) | 112,611,815 | 34,297 |
| Special Agent Squeaky's Simple Video Converter (2022) | 0 | 0 |
| Special Agent Squeaky's Simple VTubing App (2022) | 0 | 0 |
| Special Criminal Investigation (1989) | 549,593 | 387 |
| Special Force (2003) | 26,526 | 24 |
| Special Force (2004) | 52,002,132 | 6,029 |
| Special Force 2: Tale of the Truthful Pledge (2007) | 114,550 | 51 |
| Special Force II (2011) | 5,808,791 | 1,200 |
| Special Force Legion of Monsters (2024) | 12,600 | 4 |
| Special Force M : Remastered (2020) | 687,892 | 73 |
| SPECIAL FORCE VR: INFINITY WAR (2019) | 2,914,400 | 6 |
| Special Forces (1992) | 221,291,142 | 6,154 |
| Special Gulag Rescue Operation (2022) | 40 | 3 |
| Special Jinsei Game (2003) | 8,942 | 4 |
| Special Operation 85: Hostage Rescue (2007) | 2,158 | 11 |
| Special Operations (1984) | 5,420,545 | 784 |
| Special Tee Shot (1996) | 21,668 | 28 |
| The Specialists (2002) | 29,842,035 | 2,339 |
| Species: Artificial Life, Real Evolution (2018) | 42,610,107 | 278 |
| Species: Unknown (2025) | 138,660 | 172 |
| Specimen Zero - Online horror (2021) | 48,313,956 | 5,157 |
| Specnaz: Project Wolf (2006) | 82,439 | 26 |
| Spectacular Sparky (2021) | 374,333 | 171 |
| Spectar (1980) | 10,374 | 29 |
| Spectator (2023) | 42,810,027 | 1,185 |
| Specters of the Deep (2025) | 0 | 0 |
| Specters of the Sun (2025) | 107 | 5 |
| Spectipede (1983) | 3,031 | 9 |
| Spectra (2015) | 1,946,968 | 276 |
| Spectraball (2008) | 45,531 | 168 |
| Spectral Climb (2024) | 0 | 0 |
| Spectral Force 3 (2006) | 158,263 | 228 |
| Spectral Force Chronicle (2005) | 24,740 | 7 |
| Spectral Force Genesis (2008) | 135,799 | 26 |
| Spectral Force Radical Elements (2004) | 4,931 | 5 |
| Spectral Gene (2007) | 12,266 | 32 |
| Spectral Prison (2025) | 0 | 0 |
| Spectral Scream (2024) | 3,037,656 | 203 |
| Spectral Souls: Resurrection of the Ethereal Empires (2005) | 278,778 | 186 |
| Spectral vs. Generation (2005) | 656,262 | 528 |
| The Spectral Web: Hitodama (2023) | 173 | 39 |
| Spectre (1982) | 81,540,165 | 5 |
| Spectre (1991) | 3,708,935 | 255 |
