| Space Rangers 2: Dominators (2004) | 5,427,559 | 2,357 |
| Space Rangers: Quest (2016) | 290,428 | 43 |
| Space Recall (2023) | 11 | 1 |
| Space Redemption (2020) | 26 | 2 |
| Space Reign (2023) | 406,852 | 151 |
| Space Rescue (2022) | 590,041 | 231 |
| Space Rescue: Code Pink (2021) | 68,852 | 95 |
| Space Revenge (2021) | 68,329 | 62 |
| Space Roaming (2020) | 0 | 0 |
| Space Robinson (2019) | 40,013 | 52 |
| Space Robinson: Hardcore Roguelike Action (2019) | 195,938 | 97 |
| Space Robot Samurai Zombie Slayer (2015) | 539 | 6 |
| Space Rocks (2017) | 8,151 | 20 |
| Space Rocks Blaster (2021) | 1 | 1 |
| Space Rogue (1989) | 167,625 | 135 |
| Space Rogue (2016) | 124,826 | 60 |
| Space Roguelike Adventure (2022) | 113,163 | 188 |
| Space Route (2022) | 93,091 | 71 |
| Space Run (2014) | 853,650 | 969 |
| Space Run Galaxy (2016) | 0 | 0 |
| Space Salvage (2022) | 0 | 0 |
| Space Salvager (2014) | 6,508 | 8 |
| Space Scaven (2016) | 2,308 | 4 |
| Space Scavenger (2021) | 3,983,254 | 263 |
| Space Scavenger 2 (2026) | 19,444 | 26 |
| Space Scumbags (2017) | 373,927 | 29 |
| Space Sergeants (2020) | 0 | 0 |
| Space SEX (2021) | 2,870 | 1 |
| Space Shaft (2018) | 98 | 1 |
| Space Shapes (2019) | 2,164 | 3 |
| Space Shells (2022) | 4,048 | 19 |
| The Space Sheriff Spirits (2006) | 366,618 | 266 |
| Space Ship Commander (2017) | 3,100 | 2 |
| Space Ship DRIFT (2021) | 2,308 | 6 |
| Space Ship Infinity (2021) | 14 | 1 |
| Space Shrooms RollPlay (2022) | 0 | 0 |
| Space Shuttle Mission 2007 (2007) | 203,320 | 82 |
| Space Shuttle Project (1991) | 275,489 | 136 |
| Space Shuttle: A Journey into Space (1983) | 27,299 | 48 |
| Space Siege (2008) | 508,404 | 474 |
| Space Simulation Toolkit (2020) | 1,486,911 | 60 |
| Space Slaves (2023) | 7 | 1 |
| Space Slingshot VR (2018) | 995 | 3 |
| Space Slurpies (2021) | 22,304 | 51 |
| Space Smack! (2021) | 61 | 2 |
| Space Spartans (1982) | 46,136 | 27 |
| Space Sprinter VR (2020) | 0 | 0 |
| Space Sprouts (2025) | 2,155 | 17 |
| Space Spy (2009) | 972 | 4 |
| Space Squadron (2020) | 1,298 | 7 |
| Space Squash (1995) | 33,913 | 34 |
| Space Star - Heart of a Soldier (2024) | 1 | 1 |
| Space Station 13 (2003) | 71,375,534 | 9,419 |
| Space Station 51 (2021) | 0 | 0 |
| Space Station Alpha (2015) | 8,489 | 44 |
| Space Station Continuum (2020) | 22,885 | 12 |
| Space Station Defender (2024) | 722 | 3 |
| Space Station Loma: OPERATIONS (2017) | 1,398 | 8 |
| Space Station Manager (2020) | 152,931 | 12 |
| Space Station Sprint (2021) | 26,663 | 56 |
| Space Station Tycoon (2008) | 238,236 | 47 |
| Space Station Tycoon (2020) | 75,814 | 89 |
| Space Station Zulu (1982) | 564 | 2 |
| Space Station: Silicon Valley (1998) | 2,687,808 | 1,416 |
| Space Stories: Darth Star (2018) | 53 | 1 |
| Space Strike (1982) | 61,058 | 93 |
| Space Survival (2021) | 2,915,839 | 1,345 |
| Space Survivor (2024) | 1,464,976 | 516 |
| Space Survivors (2025) | 30,520 | 59 |
| Space Tactics (1980) | 12,330 | 20 |
| Space Tail: Every Journey Leads Home (2022) | 183,386 | 352 |
| Space Tail: Lost in the Sands (2022) | 17,090 | 49 |
| Space Tales (2026) | 7,047 | 17 |
| Space Tanks (2006) | 6,701 | 35 |
| Space Taxi (1984) | 201,105 | 175 |
