| Spy Kids: All the Time in the World (2011) | 3,573 | 1 |
| Spy Mouse (2011) | 4,022,850 | 171 |
| Spy Muppets: License to Croak (2003) | 333,959 | 92 |
| Spy Robot: Gateways To Humanity (2022) | 297 | 4 |
| SPY RUMBLE (2022) | 12,032,874 | 629 |
| Spy Snatcher (1992) | 438 | 3 |
| Spy Tactics (2019) | 69,418 | 54 |
| Spy vs. Spy (1984) | 1,788,218 | 439 |
| Spy vs. Spy (2005) | 2,321,096 | 238 |
| Spy vs. Spy II: The Island Caper (1985) | 133,971 | 45 |
| Spy vs. Spy III: Arctic Antics (1986) | 61,338 | 53 |
| Spy vs. Spy III: Arctic Antics (1987) | 599 | 5 |
| Spy vs. Spy: The Island Caper (1985) | 8,872 | 18 |
| The Spy Who Loved Me (1990) | 5,750,867 | 410 |
| The Spy Who Shrunk Me! (2018) | 18,799,128 | 233 |
| Spy's Demise (1982) | 7,656 | 17 |
| Spyborgs (2009) | 472,070 | 315 |
| Spycat (1988) | 1,832 | 7 |
| Spycraft: The Great Game (1996) | 301,922 | 137 |
| Spyder (2020) | 5,639,243 | 830 |
| Spyglass Board Games (2007) | 959 | 2 |
| Spyhack (2020) | 2,439 | 17 |
| SpyHunter (2001) | 1,000,464 | 529 |
| SpyHunter 2 (2003) | 560,950 | 155 |
| SpyHunter: Nowhere to Run (2006) | 2,431,461 | 336 |
| SpyParty (2018) | 135,177,756 | 1,310 |
| Spyro 2: Ripto's Rage! (1999) | 56,542,693 | 40,416 |
| Spyro 2: Season of Flame (2002) | 322,306 | 735 |
| Spyro Orange: The Cortex Conspiracy (2004) | 1,553,450 | 517 |
| Spyro Reignited Trilogy (2018) | 244,885,555 | 104,191 |
| Spyro the Dragon (1998) | 71,700,639 | 35,193 |
| Spyro: A Hero's Tail (2004) | 11,773,461 | 4,473 |
| Spyro: Attack of the Rhynocs (2003) | 396,826 | 574 |
| Spyro: Enter the Dragonfly (2002) | 9,847,073 | 4,035 |
| Spyro: Season of Ice (2001) | 712,764 | 999 |
| Spyro: Shadow Legacy (2005) | 395,073 | 258 |
| Spyro: Year of the Dragon (2000) | 62,998,069 | 30,271 |
| SQIJ! (1986) | 70,625 | 28 |
| Sqoon (1986) | 425,398 | 189 |
| Sqroma (2022) | 608 | 28 |
| Squad Assault: Second Wave (2005) | 7,499 | 11 |
| Squad Battles: Vietnam (2001) | 4,779 | 4 |
| SquadBlast (2023) | 33,842 | 74 |
| Squadron 51 (2022) | 168,801 | 85 |
| Square Deal: The Game of Two Dimensional Poker (1990) | 20,715 | 19 |
| Square Knight (2022) | 607 | 6 |
| Square Off (2009) | 333,592 | 72 |
| Square vs Triangles (2020) | 129 | 2 |
| Square's Tom Sawyer (1989) | 830,106 | 187 |
| SquareCells (2015) | 17,548 | 140 |
| Squareface (2016) | 66,262 | 47 |
| SquareMan (2022) | 1,046 | 6 |
| SquareMan-Boy (2022) | 606 | 6 |
| Squares Rage (2020) | 0 | 0 |
| SquareWorld Unpixeled (2018) | 0 | 0 |
| Squarism (2017) | 8,653 | 73 |
| Squeakers (2018) | 6,129,273 | 250 |
| Squeeballs Party (2009) | 0 | 0 |
| Squidgies Takeover (2019) | 3,443 | 5 |
| SQUIDS FROM SPACE (2017) | 1,693,056 | 83 |
| Squids Odyssey (2014) | 2,934,537 | 517 |
| Squirgle! (2008) | 1,597 | 7 |
| Squirm (2018) | 486,321 | 40 |
| Squirrel King (1995) | 795,302 | 150 |
| Squirrel Legacy (2020) | 0 | 0 |
| Squirrelmageddon! (2021) | 4,453 | 30 |
| Squirreltopia (2015) | 88,762 | 70 |
| Squish 'em (1983) | 24,649 | 54 |
| SquishCraft (2022) | 338,335 | 37 |
| Squishy Tank (2008) | 15,361 | 19 |
| Squishy the Suicidal Pig (2014) | 173,199 | 388 |
| SRD: Super Real Darwin (1987) | 175,734 | 145 |
| SRPG Studio (2018) | 132,321 | 73 |
| SRX: The Game (2021) | 1,058,564 | 1,486 |
| SSCS (2021) | 1,923 | 5 |
