| School Tycoon (2004) | 2,687,740 | 388 |
| School Years (2019) | 18,157,043 | 1,027 |
| Schoolgirl Strikers (2014) | 6,921,710 | 2,117 |
| Schoolteacher Simulator (2025) | 0 | 0 |
| Schrodinger's Catgirl (2022) | 406 | 5 |
| Schrodinger's Code (2024) | 0 | 0 |
| Schwarzerblitz (2020) | 34,167 | 151 |
| Sci-Fantasy Defence (2022) | 1,048 | 4 |
| Sci-fi builder (2023) | 82 | 2 |
| Science Girls (2022) | 24,463 | 19 |
| Science Simulator (2022) | 1,142,521 | 323 |
| Scientific Shutdown (2021) | 34 | 1 |
| Scientifically Accurate Dinosaur Mating Simulator 2021 (2021) | 27 | 1 |
| Scientifically Accurate Dinosaur Mating Simulator 2022: American Revolution 1775 - 1786 (2023) | 0 | 0 |
| SciFly: Dogfight (2008) | 1,607 | 1 |
| SciGirl: The Internship (2021) | 39,261 | 10 |
| Scion (1984) | 397,175 | 212 |
| Sciware Defense (2023) | 0 | 0 |
| Sclash (2023) | 0 | 0 |
| Sclender (2022) | 0 | 0 |
| Scooby Doo 2 - Monsters Unleashed (2004) | 958,109 | 222 |
| Scooby Doo 2 Monsters Unleashed (2004) | 1,538,878 | 122 |
| Scooby Doo! Case File #3: Frights, Camera, Mystery! (2006) | 571,283 | 27 |
| Scooby Doo: The Motion Picture (2001) | 2,102 | 16 |
| Scooby-Doo (1986) | 49,761,578 | 917 |
| Scooby-Doo (2002) | 109,263 | 9 |
| Scooby-Doo and Scrappy-Doo (1991) | 111,399 | 106 |
| Scooby-Doo and the Cyber Chase (2001) | 10,130,809 | 2,193 |
| Scooby-Doo Case File #2: The Scary Stone Dragon (2003) | 430,430 | 42 |
| Scooby-Doo in the Castle Mystery (1986) | 11,981 | 4 |
| Scooby-Doo Mystery (1995) | 44,923,132 | 1,483 |
| Scooby-Doo Mystery Cases (2018) | 312,565 | 170 |
| Scooby-Doo! and the Spooky Swamp (2010) | 45,983,964 | 1,844 |
| Scooby-Doo! Classic Creep Capers (2000) | 6,397,856 | 541 |
| Scooby-Doo! First Frights (2009) | 81,353,925 | 4,519 |
| Scooby-Doo! Jinx at the Sphinx (2000) | 5,222,883 | 42 |
| Scooby-Doo! Mystery Adventures (2000) | 21,375 | 24 |
| Scooby-Doo! Mystery Mayhem (2003) | 25,555,786 | 1,880 |
| Scooby-Doo! Mystery of the Fun Park Phantom (1999) | 365,715 | 15 |
| Scooby-Doo! Night of 100 Frights (2002) | 9,339,372 | 4,247 |
| Scooby-Doo! Phantom of the Knight (2000) | 919,383 | 54 |
| Scooby-Doo! Showdown in Ghost Town (2000) | 837,471 | 67 |
| Scooby-Doo! Unmasked (2005) | 7,338,575 | 1,755 |
| Scooby-Doo! Who's Watching Who? (2006) | 1,437,047 | 211 |
| Scooby-Doo: Jinx at the Sphinx (2001) | 0 | 0 |
| Scooby-Doo: Phantom of the Knight (2000) | 57,068 | 68 |
| Scoot Scoot (2016) | 2,638,571 | 34 |
| Scooter Shooter (1985) | 36,621 | 39 |
| Scooter War3z (2006) | 18,779 | 16 |
| Scorched 3D (2001) | 84,683 | 27 |
| Scorched Planet (1996) | 15,483 | 17 |
| Scorched Tanks (1993) | 16,732 | 16 |
| Scorcher (1996) | 461,320 | 161 |
| The Scorchfarer (2022) | 631 | 25 |
| Scorching Desert (2025) | 95,918 | 22 |
| Scorchlands (2023) | 265,742 | 197 |
| Score 3020 (1988) | 4,656 | 11 |
| SCORE International Baja 1000 (2008) | 291,297 | 108 |
| Score Rush (2010) | 39,034 | 102 |
| Score! Classic Goals (2012) | 56,689 | 13 |
| Score! Hero (2015) | 153,261,779 | 11,004 |
| Scoregasm (2011) | 27,883 | 96 |
| Scorn (2022) | 396,212,736 | 28,542 |
| Scorphius (2022) | 57 | 1 |
| The Scorpion King: Rise of the Akkadian (2002) | 1,105,730 | 272 |
| The Scorpion King: Sword of Osiris (2002) | 246,605 | 141 |
| Scorpion Overdrive (2022) | 221 | 5 |
| Scorpion's Curse (2024) | 6,728 | 2 |
| Scorpion: Disfigured (2009) | 167,193 | 198 |
| Scorpius (1988) | 7,900 | 10 |
| Scorpius (1991) | 78,184 | 11 |
| Scotophobia (2024) | 1,510 | 12 |
| Scott in Space (2015) | 589,121 | 66 |
| Scott Pilgrim vs. the World: The Game (2010) | 37,910,000 | 12,295 |
| Scott Whiskers in: the Search for Mr. Fumbleclaw (2024) | 14,018 | 142 |
