| School Girl/Zombie Hunter (2017) | 1,592,651 | 2,298 |
| School Hero (2025) | 11,804 | 72 |
| School of Dragons (2014) | 110,051,858 | 6,715 |
| School of Magic (2022) | 1,794,731 | 146 |
| School Panic (1987) | 2,134 | 14 |
| School Paranormal Laboratory (2024) | 2,064 | 16 |
| School Rumble: Neru Musume wa Sodatsu (2005) | 2,612 | 1 |
| School Tycoon (2004) | 2,688,360 | 392 |
| School Years (2019) | 18,567,336 | 1,097 |
| Schoolgirl Strikers (2014) | 6,921,710 | 2,117 |
| Schoolteacher Simulator (2025) | 298,996 | 72 |
| Schrodinger's Catgirl (2022) | 406 | 5 |
| Schrodinger's Code (2024) | 0 | 0 |
| Schwarzerblitz (2020) | 34,895 | 159 |
| Sci-Fantasy Defence (2022) | 1,048 | 4 |
| Sci-fi builder (2023) | 82 | 2 |
| Science Girls (2022) | 24,477 | 20 |
| Science Simulator (2022) | 1,142,521 | 323 |
| Scientific Shutdown (2021) | 34 | 1 |
| Scientifically Accurate Dinosaur Mating Simulator 2021 (2021) | 27 | 1 |
| Scientifically Accurate Dinosaur Mating Simulator 2022: American Revolution 1775 - 1786 (2023) | 0 | 0 |
| SciFly: Dogfight (2008) | 1,607 | 1 |
| SciGirl: The Internship (2021) | 39,261 | 10 |
| Scion (1984) | 548,834 | 298 |
| Sciware Defense (2023) | 0 | 0 |
| Sclash (2023) | 1,643,252 | 489 |
| Sclender (2022) | 0 | 0 |
| Scooby Doo 2 - Monsters Unleashed (2004) | 961,123 | 231 |
| Scooby Doo 2 Monsters Unleashed (2004) | 1,539,146 | 124 |
| Scooby Doo! Case File #3: Frights, Camera, Mystery! (2006) | 571,283 | 27 |
| Scooby Doo: The Motion Picture (2001) | 2,118 | 19 |
| Scooby-Doo (1986) | 49,781,529 | 927 |
| Scooby-Doo (2002) | 109,263 | 9 |
| Scooby-Doo and Scrappy-Doo (1991) | 111,820 | 110 |
| Scooby-Doo and the Cyber Chase (2001) | 10,186,054 | 2,271 |
| Scooby-Doo Case File #2: The Scary Stone Dragon (2003) | 430,435 | 43 |
| Scooby-Doo in the Castle Mystery (1986) | 12,044 | 5 |
| Scooby-Doo Mystery (1995) | 46,413,949 | 1,581 |
| Scooby-Doo Mystery Cases (2018) | 312,573 | 170 |
| Scooby-Doo! and the Spooky Swamp (2010) | 46,011,947 | 1,922 |
| Scooby-Doo! Classic Creep Capers (2000) | 6,480,904 | 574 |
| Scooby-Doo! First Frights (2009) | 81,509,043 | 4,677 |
| Scooby-Doo! Jinx at the Sphinx (2000) | 5,302,517 | 43 |
| Scooby-Doo! Mystery Adventures (2000) | 21,695 | 26 |
| Scooby-Doo! Mystery Mayhem (2003) | 25,580,960 | 1,979 |
| Scooby-Doo! Mystery of the Fun Park Phantom (1999) | 366,425 | 19 |
| Scooby-Doo! Night of 100 Frights (2002) | 9,431,946 | 4,582 |
| Scooby-Doo! Phantom of the Knight (2000) | 955,247 | 57 |
| Scooby-Doo! Showdown in Ghost Town (2000) | 845,588 | 72 |
| Scooby-Doo! Unmasked (2005) | 7,377,785 | 1,917 |
| Scooby-Doo! Who's Watching Who? (2006) | 1,437,405 | 217 |
| Scooby-Doo: Jinx at the Sphinx (2001) | 568,560 | 51 |
| Scooby-Doo: Phantom of the Knight (2000) | 58,364 | 74 |
| Scoot Scoot (2016) | 2,638,571 | 34 |
| Scooter Shooter (1985) | 39,767 | 40 |
| Scooter War3z (2006) | 18,779 | 16 |
| Scorched 3D (2001) | 84,683 | 27 |
| Scorched Planet (1996) | 15,488 | 17 |
| Scorched Tanks (1993) | 16,732 | 16 |
| Scorcher (1996) | 470,170 | 168 |
| The Scorchfarer (2022) | 631 | 25 |
| Scorching Desert (2025) | 96,492 | 24 |
| Scorchlands (2023) | 265,756 | 198 |
| Score 3020 (1988) | 4,660 | 11 |
| SCORE International Baja 1000 (2008) | 294,702 | 196 |
| Score Rush (2010) | 39,044 | 103 |
| Score! Classic Goals (2012) | 56,702 | 13 |
| Score! Hero (2015) | 153,371,301 | 11,124 |
| Scoregasm (2011) | 27,883 | 96 |
| Scorn (2022) | 401,181,738 | 28,860 |
| Scorphius (2022) | 57 | 1 |
| The Scorpion King: Rise of the Akkadian (2002) | 1,106,027 | 304 |
| The Scorpion King: Sword of Osiris (2002) | 246,838 | 142 |
| Scorpion Overdrive (2022) | 221 | 5 |
| Scorpion's Curse (2024) | 6,728 | 2 |
