| Sammy Lightfoot (1983) | 48,140 | 43 |
| Sammy Sosa High Heat Baseball 2001 (2000) | 37,653 | 58 |
| Sammy Sosa Softball Slam (2000) | 101,122 | 45 |
| SAMOLIOTIK (2016) | 58,428 | 40 |
| Samorost (2003) | 2,219,597 | 1,446 |
| Samorost 2 (2005) | 2,881,853 | 1,181 |
| Samorost 3 (2016) | 22,782,841 | 3,880 |
| Samozbor ID:HEAVEN (2020) | 918 | 4 |
| Samozbor: Rebellion (2018) | 172 | 1 |
| Sample Gunpowder (2024) | 0 | 0 |
| Sampras Tennis 96 (1995) | 10,671 | 29 |
| Samsa and the Knights of Light (2015) | 11,184 | 6 |
| Samsara (2018) | 1,751,407 | 936 |
| Samsara Room (2020) | 13,521,941 | 1,882 |
| SAMUDRA (2021) | 6,308,584 | 1,151 |
| Samuel Sage: The Mystery at Penby Inn (2024) | 75 | 3 |
| Samurai Aces (1993) | 608,696 | 508 |
| Samurai Bringer (2022) | 1,543,625 | 900 |
| SAMURAI CHALLENGE (2022) | 143,038 | 19 |
| Samurai Champloo: Sidetracked (2006) | 586,062 | 453 |
| Samurai Deeper Kyo (2002) | 444,827 | 362 |
| Samurai Defender (2013) | 80,996 | 46 |
| Samurai Gunn (2013) | 4,012,959 | 155 |
| Samurai Gunn 2 (2020) | 1,074,398 | 133 |
| Samurai II: Vengeance (2010) | 4,978,068 | 1,361 |
| Samurai Jack: Battle Through Time (2020) | 24,527,052 | 8,407 |
| Samurai Jack: The Amulet of Time (2003) | 924,412 | 116 |
| Samurai Jack: The Shadow of Aku (2004) | 1,529,160 | 671 |
| SAMURAI MAIDEN (2022) | 3,254,232 | 4,401 |
| Samurai of Hyuga (2016) | 1,017 | 1 |
| Samurai of Hyuga Book 2 (2016) | 0 | 0 |
| Samurai of Hyuga Book 3 (2017) | 0 | 0 |
| Samurai of Hyuga Book 4 (2019) | 0 | 0 |
| Samurai of Hyuga Book 5 (2022) | 0 | 0 |
| Samurai Qrsento (2024) | 0 | 0 |
| Samurai Riot (2017) | 86,095 | 169 |
| Samurai Shampoo (2021) | 1,759 | 29 |
| Samurai Shiba (2024) | 0 | 0 |
| Samurai Shodown (1993) | 19,151,436 | 6,506 |
| Samurai Shodown (2019) | 63,728,194 | 35,653 |
| Samurai Shodown 64 (1997) | 647,537 | 304 |
| Samurai Shodown 64: Warriors Rage (1998) | 259,181 | 276 |
| Samurai Shodown Anthology (2008) | 579,907 | 291 |
| Samurai Shodown II (1994) | 17,277,550 | 11,565 |
| Samurai Shodown III (1995) | 3,498,065 | 2,791 |
| Samurai Shodown IV: Amakusa's Revenge (1996) | 3,561,699 | 5,823 |
| SAMURAI SHODOWN NEOGEO COLLECTION (2020) | 1,186,155 | 1,482 |
| Samurai Shodown Sen (2008) | 2,610,085 | 1,058 |
| Samurai Shodown V (2003) | 16,562,452 | 11,766 |
| Samurai Shodown VI (2005) | 4,448,096 | 2,506 |
| Samurai Shodown! 2 (1999) | 1,075,136 | 584 |
| Samurai Shodown: Warriors Rage (1999) | 724,355 | 708 |
| Samurai Siege (2013) | 415,401 | 145 |
| Samurai Slaughter House (2022) | 231,850 | 105 |
| Samurai Solitaire. Threads of Fate (2022) | 2,125 | 3 |
| Samurai Sword (1988) | 905,588 | 118 |
| Samurai Sword Destiny (2012) | 58,305 | 13 |
| Samurai Sword VR (2017) | 6,185 | 7 |
| Samurai Warrior: The Battles of Usagi Yojimbo (1988) | 193,305 | 65 |
| Samurai Warriors (2004) | 41,670,596 | 12,693 |
| Samurai Warriors 2 (2006) | 19,106,232 | 10,965 |
| Samurai Warriors 3 (2009) | 17,951,700 | 5,587 |
| Samurai Warriors 4 (2014) | 56,603,718 | 22,498 |
| Samurai Warriors 5 (2021) | 21,351,009 | 23,712 |
| Samurai Warriors Chronicles 2nd (2012) | 18,634 | 7 |
| Samurai Warriors Chronicles 3 (2014) | 625,630 | 364 |
| Samurai Warriors: Chronicles (2011) | 1,450,944 | 622 |
| Samurai Warriors: Chronicles 2nd (2012) | 2,962 | 3 |
| Samurai Warriors: Katana (2007) | 267,256 | 171 |
| Samurai Warriors: Sanada Maru (2016) | 264,771 | 97 |
| Samurai Warriors: Spirit of Sanada (2016) | 5,057,900 | 4,206 |
| Samurai Warriors: State of War (2005) | 3,812 | 15 |
| Samurai Western (2005) | 1,035,218 | 700 |
| Samurai Wish (2018) | 554 | 10 |
| Samurai-Ghost (1992) | 1,292,019 | 237 |
