| Samantha Fox Strip Poker (1986) | 198,644 | 34 |
| Samantha Swift and the Golden Touch (2009) | 52,260 | 41 |
| Samantha Swift and the Hidden Roses of Athena (2008) | 202,047 | 76 |
| Samawa Idle (2023) | 34,843 | 48 |
| Samba de Amigo (1999) | 2,655,606 | 434 |
| Samba de Amigo (2008) | 8,322,841 | 473 |
| Samba de Amigo ver. 2000 (2000) | 183,810 | 76 |
| Same Game (1992) | 1,697,490 | 232 |
| Same Room Same Day (2025) | 48,255 | 136 |
| SameGame (1999) | 58 | 2 |
| SameGame (2008) | 3 | 1 |
| SameShadow: Fernando's Journey (2024) | 160 | 4 |
| Samhain World (2017) | 0 | 0 |
| Samira's House (2024) | 482 | 5 |
| Sammy Jukes: Twin Lakes (2024) | 4,606 | 55 |
| Sammy Lightfoot (1983) | 48,145 | 43 |
| Sammy Sosa High Heat Baseball 2001 (2000) | 37,746 | 59 |
| Sammy Sosa Softball Slam (2000) | 101,122 | 45 |
| SAMOLIOTIK (2016) | 58,428 | 40 |
| Samorost (2003) | 2,220,397 | 1,459 |
| Samorost 2 (2005) | 2,886,145 | 1,197 |
| Samorost 3 (2016) | 22,791,305 | 3,903 |
| Samozbor ID:HEAVEN (2020) | 918 | 4 |
| Samozbor: Rebellion (2018) | 172 | 1 |
| Sample Gunpowder (2024) | 0 | 0 |
| Sampras Tennis 96 (1995) | 10,671 | 29 |
| Samsa and the Knights of Light (2015) | 11,184 | 6 |
| Samsara (2018) | 1,749,255 | 937 |
| Samsara Room (2020) | 13,522,689 | 1,890 |
| SAMUDRA (2021) | 6,309,805 | 1,155 |
| Samuel Sage: The Mystery at Penby Inn (2024) | 75 | 3 |
| SAMUKID (2026) | 0 | 0 |
| Samurai Aces (1993) | 609,004 | 509 |
| Samurai beat demons (2026) | 0 | 0 |
| Samurai Bringer (2022) | 1,543,630 | 900 |
| SAMURAI CHALLENGE (2022) | 143,038 | 19 |
| Samurai Champloo: Sidetracked (2006) | 586,556 | 454 |
| Samurai Conqueror (2026) | 0 | 0 |
| Samurai Deeper Kyo (2002) | 445,371 | 362 |
| Samurai Defender (2013) | 80,996 | 46 |
| Samurai Gunn (2013) | 4,012,959 | 155 |
| Samurai Gunn 2 (2020) | 1,074,788 | 135 |
| Samurai II: Vengeance (2010) | 4,978,394 | 1,362 |
| Samurai Jack: Battle Through Time (2020) | 24,528,277 | 8,446 |
| Samurai Jack: The Amulet of Time (2003) | 926,068 | 118 |
| Samurai Jack: The Shadow of Aku (2004) | 1,531,325 | 673 |
| SAMURAI MAIDEN (2022) | 3,382,472 | 4,403 |
| Samurai of Hyuga (2016) | 1,017 | 1 |
| Samurai of Hyuga Book 2 (2016) | 0 | 0 |
| Samurai of Hyuga Book 3 (2017) | 0 | 0 |
| Samurai of Hyuga Book 4 (2019) | 0 | 0 |
| Samurai of Hyuga Book 5 (2022) | 0 | 0 |
| Samurai Qrsento (2024) | 0 | 0 |
| Samurai Riot (2017) | 86,096 | 169 |
| Samurai Shampoo (2021) | 1,759 | 29 |
| Samurai Shiba (2024) | 0 | 0 |
| Samurai Shodown (1993) | 19,186,958 | 6,509 |
| Samurai Shodown (2019) | 63,734,434 | 35,663 |
| Samurai Shodown 64 (1997) | 647,710 | 305 |
| Samurai Shodown 64: Warriors Rage (1998) | 259,910 | 277 |
| Samurai Shodown Anthology (2008) | 579,909 | 291 |
| Samurai Shodown II (1994) | 17,356,212 | 11,679 |
| Samurai Shodown III (1995) | 3,509,337 | 2,816 |
| Samurai Shodown IV: Amakusa's Revenge (1996) | 3,568,078 | 5,862 |
| SAMURAI SHODOWN NEOGEO COLLECTION (2020) | 1,186,253 | 1,482 |
| Samurai Shodown Sen (2008) | 2,610,175 | 1,059 |
| Samurai Shodown V (2003) | 16,639,527 | 11,901 |
| Samurai Shodown VI (2005) | 4,448,769 | 2,509 |
| Samurai Shodown! 2 (1999) | 1,075,334 | 584 |
| Samurai Shodown: Warriors Rage (1999) | 777,573 | 715 |
| Samurai Siege (2013) | 415,401 | 145 |
| Samurai Slaughter House (2022) | 231,850 | 105 |
| Samurai Solitaire. Threads of Fate (2022) | 2,125 | 3 |
| Samurai Sword (1988) | 905,705 | 119 |
| Samurai Sword Destiny (2012) | 58,305 | 13 |
