| SimCity Social (2012) | 298,869 | 145 |
| SimCity Societies (2007) | 4,700,310 | 539 |
| SimCopter (1996) | 1,178,157 | 234 |
| Sime Is Back 3D Old School (2024) | 196 | 7 |
| SimEarth (1990) | 1,255,814 | 315 |
| SimFarm (1993) | 536,991 | 131 |
| SimGolf (1996) | 50,283 | 46 |
| SimHealth (1994) | 488,915 | 4 |
| Similariddle (2026) | 0 | 0 |
| Similo: The Card Game (2020) | 144,589 | 63 |
| SimIsle: Missions in the Rainforest (1995) | 52,361 | 24 |
| SimLife (1992) | 53,605 | 55 |
| Simmetri (2018) | 0 | 0 |
| Simmiland (2018) | 6,368,053 | 365 |
| Simon Clone (2010) | 1,536 | 2 |
| Simon the Sorcerer (1993) | 2,575,819 | 3,566 |
| Simon the Sorcerer 3D (2002) | 164,124 | 284 |
| Simon the Sorcerer 4: Chaos Happens (2007) | 240,504 | 444 |
| Simon the Sorcerer II: The Lion, the Wizard and the Wardrobe (1995) | 636,349 | 1,181 |
| Simon the Sorcerer Origins (2025) | 242 | 14 |
| Simon the Sorcerer's Puzzle Pack (1998) | 460 | 3 |
| Simon the Sorcerer: Who'd Even Want Contact (2009) | 3,642 | 51 |
| Simona's Requiem (2021) | 24,836 | 56 |
| Simp Simulator (2020) | 482,180 | 43 |
| SIMP: Super Infection Massive Pathology (2024) | 109 | 3 |
| SimPark (1996) | 43,666 | 46 |
| Simple 1500 Series Vol.21 -The Baseball (2000) | 1,537 | 18 |
| Simple 500 Series Vol. 2: The Misshitsu Kara no Dasshutsu (2008) | 131,158 | 17 |
| Simple Dot (2019) | 424 | 9 |
| Simple DS Series Vol. 27: The Misshitsu kara no Dasshutsu: The Suiri Bangai-hen (2007) | 114,213 | 27 |
| Simple DS Series Vol. 42: The Haioku Byoutou (2008) | 33,644 | 7 |
| Simple DS Series Vol. 45: The Misshitsu kara no Dasshutsu 2 (2008) | 306,113 | 61 |
| Simple DS Series Vol. 47: The Suiri Shinshou 2009 (2009) | 274 | 2 |
| Simple Game (2023) | 1,846,228 | 545 |
| Simple Rolling (2022) | 3,498 | 15 |
| Simple RPG (2010) | 4,000 | 14 |
| Simple Sanguo (2024) | 0 | 0 |
| Simple Story - Alex (2018) | 559 | 18 |
| Simple Trains (2023) | 6,022 | 7 |
| Simple Video Merger (2023) | 0 | 0 |
| Simplefield (2017) | 132 | 2 |
| SimplePlanes (2014) | 98,625,124 | 4,388 |
| SimplePlanes 2 (2026) | 260,959 | 7 |
| Simpler Times (2024) | 188,220 | 124 |
| Simplest RPG Game - Text Adventure (2020) | 9,006 | 9 |
| simpliCity (2023) | 2,922,610 | 251 |
| Simplode Suite (2020) | 0 | 0 |
| Simply Chess (2015) | 16,986 | 105 |
| Simply Hard Platformer (2020) | 0 | 0 |
| Simply Puzzles: Codewords (2020) | 9 | 1 |
| Simply Puzzles: Junctions (2020) | 49 | 1 |
| Simply Rotate (2024) | 88 | 3 |
| Simpocalypse (2020) | 712,918 | 117 |
| SimPoly Drive (2023) | 12 | 1 |
| The Simpsons Arcade (2009) | 14,287,394 | 2,737 |
| The Simpsons Bowling (2000) | 312,740 | 185 |
| The Simpsons Game (2007) | 214,004,156 | 10,171 |
| The Simpsons Skateboarding (2002) | 6,465,205 | 452 |
| The Simpsons Wrestling (2001) | 4,455,063 | 1,001 |
| The Simpsons: Bart vs. The Juggernauts (1992) | 206,055 | 94 |
| The Simpsons: Bart vs. the Space Mutants (1991) | 26,886,546 | 1,736 |
| The Simpsons: Bart vs. the World (1991) | 1,040,733 | 626 |
| The Simpsons: Bart's House of Weirdness (1991) | 518,146 | 74 |
| The Simpsons: Bart's Nightmare (1992) | 11,276,739 | 1,086 |
| The Simpsons: Bartman Meets Radioactive Man (1992) | 9,340,911 | 346 |
| The Simpsons: Cartoon Studio (1996) | 815,728 | 132 |
| The Simpsons: Minutes to Meltdown (2007) | 372,606 | 48 |
| The Simpsons: Night of the Living Treehouse of Horror (2001) | 3,038,298 | 194 |
| The Simpsons: Road Rage (2001) | 128,870,940 | 7,162 |
| The Simpsons: Tapped Out (2012) | 99,384,364 | 10,905 |
| The Simpsons: Virtual Springfield (1997) | 4,765,681 | 107 |
| SimRail - The Railway Simulator (2023) | 22,544,707 | 5,064 |
| SimRefinery (1992) | 223,925 | 8 |
| The Sims (2000) | 1,834,915,112 | 53,805 |
| The Sims 2 (2004) | 558,941,284 | 83,410 |
