| The Simpsons: Bart vs. the World (1991) | 1,049,769 | 630 |
| The Simpsons: Bart's House of Weirdness (1991) | 518,146 | 74 |
| The Simpsons: Bart's Nightmare (1992) | 11,276,739 | 1,086 |
| The Simpsons: Bartman Meets Radioactive Man (1992) | 9,342,213 | 347 |
| The Simpsons: Cartoon Studio (1996) | 815,728 | 132 |
| The Simpsons: Minutes to Meltdown (2007) | 372,606 | 48 |
| The Simpsons: Night of the Living Treehouse of Horror (2001) | 3,038,298 | 194 |
| The Simpsons: Road Rage (2001) | 128,875,235 | 7,166 |
| The Simpsons: Tapped Out (2012) | 99,440,989 | 10,906 |
| The Simpsons: Virtual Springfield (1997) | 4,765,681 | 107 |
| SimRail - The Railway Simulator (2023) | 22,545,454 | 5,064 |
| SimRefinery (1992) | 223,925 | 8 |
| The Sims (2000) | 1,835,447,981 | 53,818 |
| The Sims 2 (2004) | 558,944,214 | 83,411 |
| The Sims 2: Apartment Pets (2008) | 166,997 | 421 |
| The Sims 2: Castaway (2007) | 13,063,210 | 1,844 |
| The Sims 2: Double Deluxe (2008) | 122,694 | 39 |
| The Sims 3 (2009) | 2,105,910,445 | 152,097 |
| The Sims 4 (2014) | 22,868,268,698 | 1,069,088 |
| The Sims Bustin' Out (2003) | 14,238,280 | 4,459 |
| The Sims Carnival: Snap City (2008) | 13,640 | 11 |
| The Sims Castaway Stories (2008) | 8,267,161 | 1,029 |
| The Sims FreePlay (2011) | 198,257,636 | 17,290 |
| The Sims Life Stories (2007) | 8,096,619 | 1,007 |
| The Sims Medieval (2011) | 44,499,581 | 6,199 |
| The Sims Mobile (2018) | 67,663,321 | 7,639 |
| The Sims Online (2002) | 11,217,381 | 501 |
| The Sims Pet Stories (2007) | 463,414 | 454 |
| The Sims Social (2011) | 1,928,440 | 164 |
| SimSafari (1998) | 288,054 | 29 |
| Simson Tuningwerkstatt 3D (2018) | 202 | 1 |
| SimTower (1994) | 1,780,453 | 339 |
| SimTown (1995) | 282,293 | 49 |
| SimTunes (1996) | 13,292 | 12 |
| Simulacra (2017) | 152,772,299 | 3,269 |
| SIMULACRA 2 (2019) | 34,518,278 | 1,669 |
| SIMULACRA 3 (2022) | 367 | 19 |
| SIMULACRA: Pipe Dreams (2018) | 6,260,761 | 325 |
| The Simulacrum (2023) | 3,043,671 | 510 |
| Simulakros (2024) | 120,357 | 62 |
| Simulation Pro Yakyuu (1995) | 2,404 | 22 |
| Simulation RPG Tsukuru (1998) | 969 | 5 |
| Simulation Training Room: Massacre (2024) | 33 | 2 |
| Simulator of Countries (2024) | 9,499 | 23 |
| Simulator of Ukraine 1991 (2024) | 15,844 | 14 |
| Simulator: Parking Lot (2024) | 9,406 | 10 |
| Simulcra (1990) | 10,251 | 30 |
| Simultaneous Control (2022) | 52 | 3 |
| Simutrans (1999) | 775,523 | 2,364 |
| SiN (1998) | 45,334,541 | 3,436 |
| Sin and Punishment (2000) | 3,652,933 | 1,722 |
| SIN CARDS: Welcome to the Netherworld (2025) | 0 | 0 |
| The Sin Collector: Repentless (2021) | 28,667 | 18 |
| SiN Episodes (2006) | 2,415,780 | 781 |
| Sin Slayers (2019) | 486,389 | 339 |
| Sin Slayers: Reign of The 8th (2024) | 61,269 | 83 |
| Sin'geom-ui Jeonseol - Dream Traveler Part 1 (1987) | 3,962 | 14 |
| Sinbad and the Throne of the Falcon (1987) | 40,018 | 25 |
| Sinderfury (2024) | 105 | 6 |
| Sine Mora (2012) | 4,331,523 | 2,267 |
| Sing Party (2012) | 476,548 | 153 |
| Singalongsong (2024) | 0 | 0 |
| Singaria (2019) | 7,548 | 7 |
| The Singing Saw Simulator (2024) | 11 | 3 |
| single spark (2025) | 0 | 0 |
| Singled Out (2019) | 43,579,710 | 48 |
| SingStar (2004) | 12,935 | 18 |
| SingStar (2007) | 102,701 | 25 |
| SingStar '80s (2007) | 149,489 | 32 |
| SingStar 90s (2007) | 14,256 | 7 |
| SingStar ABBA (2008) | 64,046 | 18 |
| SingStar Amped (2007) | 24,642 | 8 |
| SingStar Anthems (2006) | 3,805 | 4 |
| SingStar Bollywood (2007) | 69 | 1 |
| SingStar Celebration (2017) | 795,631 | 67 |
