| Sakura Succubus 5 (2022) | 40,903 | 190 |
| Sakura Succubus 6 (2022) | 32,386 | 145 |
| Sakura Succubus 7 (2023) | 8,919 | 76 |
| Sakura Succubus 8 (2024) | 2,740 | 14 |
| Sakura Swim Club (2015) | 3,259,686 | 784 |
| Sakura Taisen (1996) | 4,326,635 | 2,485 |
| Sakura Taisen 2: Kimi, Shinitamou koto Nakare (1998) | 956,138 | 1,376 |
| Sakura Taisen GB (2000) | 24,504 | 22 |
| Sakura Taisen GB2 (2001) | 4,336 | 6 |
| Sakura Taisen Monogatari: Mysterious Paris (2004) | 595 | 4 |
| Sakura Taisen V Episode 0: Arano no Samurai Musume (2004) | 3,275 | 9 |
| Sakura Taisen: Atsuki Chishio ni (2003) | 113,959 | 356 |
| Sakura Wars (2019) | 23,480,048 | 16,157 |
| Sakura Wars 4: Fall in Love, Maidens (2002) | 460,888 | 916 |
| Sakura Wars: So Long, My Love (2005) | 1,511,375 | 1,832 |
| Sakuya Izayoi Gives You Advice And Dabs (2020) | 44,000 | 37 |
| Salad Bar Tycoon (2020) | 1,705 | 29 |
| Salad Fields (2020) | 1,445 | 27 |
| Salamander (1986) | 13,596,954 | 6,791 |
| Salamander 2 (1996) | 1,583,212 | 379 |
| Salammbo: Battle for Carthage (2002) | 22,723 | 47 |
| Salaryman Champ (2001) | 148,249 | 25 |
| Salaryman Shi (2022) | 11,237 | 34 |
| Saleblazers (2023) | 1,509,859 | 467 |
| Salem (2015) | 7,110,854 | 703 |
| Sales employee Takeru-Kun (2024) | 0 | 0 |
| Sally Face (2016) | 449,169,494 | 15,504 |
| Sally's Law (2016) | 288,426 | 144 |
| Sally's Salon (2007) | 707,489 | 622 |
| Sally's Spa (2008) | 155,774 | 262 |
| Salmon Run (1982) | 4,858,494 | 2,162 |
| Salome's Kiss (2022) | 2,544 | 3 |
| Salon Superstar (2009) | 790 | 12 |
| Saloon VR (2019) | 1,347,305 | 10 |
| Salt (2013) | 5,894,266 | 1,035 |
| Salt 2: Shores of Gold (2022) | 2,845,392 | 1,260 |
| Salt and Sacrifice (2022) | 9,239,508 | 11,040 |
| Salt and Sanctuary (2016) | 45,561,227 | 32,049 |
| Salt Lake 2002 (2002) | 770,533 | 97 |
| Saltsea Chronicles (2023) | 0 | 0 |
| SALTWATER (2025) | 451 | 3 |
| Salty Hounds (2023) | 8,064 | 28 |
| Salus per aquam (2024) | 36 | 1 |
| Salvage (1985) | 4,729,816 | 352 |
| Salvando la Isla Perdida (2022) | 0 | 0 |
| Salvation Hours (2024) | 1,421 | 5 |
| Salvation of Sisyphus (2024) | 0 | 0 |
| Salvation Prophecy (2012) | 342,677 | 134 |
| SALVATIONLAND (2023) | 8,773 | 9 |
| Salvo Shuffle (2024) | 32 | 1 |
| Salvo Subs (2025) | 0 | 0 |
| Sam & Dan: Floaty Flatmates (2018) | 29,337,225 | 85 |
| Sam & Max Beyond Time and Space (2007) | 1,845,561 | 1,570 |
| Sam & Max Save the World (2006) | 4,047,551 | 2,287 |
| Sam & Max: The Devil's Playhouse (2010) | 0 | 0 |
| Sam & Max: This Time It's Virtual! (2021) | 1,516,897 | 215 |
| Sam Power: Footballer (2009) | 6,427 | 4 |
| Samantha Fox Strip Poker (1986) | 198,621 | 33 |
| Samantha Swift and the Golden Touch (2009) | 52,260 | 41 |
| Samantha Swift and the Hidden Roses of Athena (2008) | 202,039 | 76 |
| Samawa Idle (2023) | 34,402 | 41 |
| Samba de Amigo (1999) | 2,653,857 | 433 |
| Samba de Amigo (2008) | 8,313,322 | 437 |
| Samba de Amigo ver. 2000 (2000) | 183,433 | 74 |
| Same Game (1992) | 1,566,991 | 220 |
| Same Room Same Day (2025) | 35,057 | 125 |
| SameGame (1999) | 58 | 2 |
| SameGame (2008) | 3 | 1 |
| SameShadow: Fernando's Journey (2024) | 160 | 4 |
| Samhain World (2017) | 0 | 0 |
| Samira's House (2024) | 482 | 5 |
| Sammy Jukes: Twin Lakes (2024) | 4,601 | 55 |
| Sammy Lightfoot (1983) | 48,134 | 43 |
| Sammy Sosa High Heat Baseball 2001 (2000) | 37,653 | 58 |
| Sammy Sosa Softball Slam (2000) | 101,107 | 44 |
