| Saint Seiya: Ougon Densetsu Kanketsu Hen (1988) | 1,562,140 | 373 |
| Saint Seiya: Sanctuary Battle (2011) | 11,363,477 | 2,232 |
| Saint Seiya: Soldiers' Soul (2015) | 67,502,315 | 32,262 |
| Saint Seiya: The Hades (2006) | 7,296,726 | 3,206 |
| Saint Seiya: The Sanctuary (2005) | 4,974,175 | 2,239 |
| Saint Seiya: Typing Ryu Sei Ken (2003) | 132,984 | 16 |
| Saint Slaughter X Days (2018) | 0 | 0 |
| Saint Sword (1991) | 206,052 | 174 |
| The Saint: Abyss of Despair (2017) | 8,856 | 48 |
| Sainthood (2024) | 6,691 | 19 |
| Saints of Virtue (1999) | 183,206 | 6 |
| Saints Row (2006) | 54,814,512 | 17,852 |
| Saints Row (2022) | 175,191,707 | 93,851 |
| Saints Row 2 (2008) | 160,246,417 | 47,896 |
| Saints Row Double Pack (2010) | 346 | 2 |
| Saints Row IV (2013) | 643,300,990 | 125,283 |
| Saints Row: The Third (2011) | 558,442,188 | 115,173 |
| Sairento VR (2018) | 5,898,489 | 1,640 |
| Saiyuki: Journey West (2001) | 532,387 | 1,201 |
| Saki - sakuseikan. (2023) | 0 | 0 |
| Saki Portable (2010) | 121,720 | 116 |
| Sakuna: Of Rice and Ruin (2020) | 67,585,470 | 36,530 |
| Sakura Agent (2017) | 128,378 | 90 |
| Sakura Alien (2022) | 252,278 | 140 |
| Sakura Alien 2 (2022) | 5,230 | 75 |
| Sakura and Crit: The Mock Game (2018) | 28 | 1 |
| Sakura Angels (2015) | 3,744,838 | 676 |
| Sakura Beach (2015) | 997,382 | 342 |
| Sakura Beach 2 (2015) | 522,939 | 201 |
| Sakura Bunny Girls (2023) | 42,101 | 51 |
| Sakura Clicker (2015) | 2,473,770 | 266 |
| Sakura Cupid (2018) | 279,178 | 110 |
| Sakura Dungeon (2016) | 3,659,824 | 793 |
| Sakura Fantasy (2015) | 5,680,867 | 519 |
| Sakura Forest Girls (2021) | 4,661 | 46 |
| Sakura Forest Girls 2 (2021) | 3,175 | 31 |
| Sakura Forest Girls 3 (2021) | 2,177 | 29 |
| Sakura Fox Adventure (2019) | 69,882 | 33 |
| Sakura Gamer (2017) | 387,185 | 105 |
| Sakura Gamer 2 (2019) | 35,020 | 29 |
| Sakura Gym Girls (2022) | 6,880 | 41 |
| Sakura Hime (2021) | 42,926 | 32 |
| Sakura Hime 2 (2022) | 12,510 | 19 |
| Sakura Hime 3 (2022) | 1,504 | 5 |
| Sakura Hime 4 (2024) | 195 | 1 |
| Sakura In Gameland (2021) | 1,282 | 2 |
| Sakura in Paris (2023) | 2 | 1 |
| Sakura Isekai Adventure (2024) | 2,276 | 14 |
| Sakura Isekai Adventure 2 (2024) | 4,478 | 11 |
| Sakura Kanji Ketchi (2023) | 0 | 0 |
| Sakura Knight (2020) | 24,019 | 34 |
| Sakura Knight 2 (2020) | 35,233 | 35 |
| Sakura Knight 3 (2020) | 17,467 | 20 |
| Sakura Magical Girls (2017) | 258,355 | 159 |
| Sakura Melody (2022) | 4,084 | 30 |
| Sakura Mirror (2022) | 453 | 4 |
| Sakura MMO (2018) | 53,565 | 140 |
| Sakura MMO 2 (2019) | 19,353 | 83 |
| Sakura MMO 3 (2019) | 26,308 | 93 |
| Sakura MMO Extra (2021) | 8,500 | 40 |
| Sakura Momoko no Ukiuki Carnival (2002) | 228,734 | 85 |
| Sakura Note: Ima ni Tsunagaru Mirai (2009) | 9,548 | 44 |
| Sakura Nova (2016) | 460,265 | 327 |
| Sakura Sadist (2018) | 87,227 | 67 |
| Sakura Sakura (2018) | 738,362 | 238 |
| Sakura Samurai: Art of the Sword (2011) | 239,646 | 84 |
| Sakura Santa (2015) | 2,540,595 | 656 |
| SAKURA School Simulator (2022) | 13,110,709,857 | 108,808 |
| Sakura Shadow Monsters (2023) | 16 | 1 |
| Sakura Shrine Girls (2016) | 456,932 | 267 |
| Sakura Space (2016) | 254,359 | 118 |
| Sakura Spirit (2014) | 21,823,546 | 1,185 |
| Sakura Stars (2020) | 11,320 | 8 |
| Sakura Succubus (2020) | 298,885 | 446 |
| Sakura Succubus 2 (2020) | 200,906 | 376 |
