| SpyFall (2026) | 2,879 | 1 |
| Spyglass Board Games (2007) | 3,431 | 4 |
| Spyhack (2020) | 4,133 | 18 |
| SpyHunter (2001) | 1,135,216 | 481 |
| SpyHunter 2 (2003) | 589,990 | 177 |
| SpyHunter: Nowhere to Run (2006) | 2,765,397 | 362 |
| SpyParty (2018) | 123,596,281 | 1,326 |
| Spyro 2: Ripto's Rage! (1999) | 62,065,862 | 46,973 |
| Spyro 2: Season of Flame (2002) | 332,327 | 828 |
| Spyro Orange: The Cortex Conspiracy (2004) | 1,806,685 | 615 |
| Spyro Reignited Trilogy (2018) | 229,964,036 | 114,681 |
| Spyro the Dragon (1998) | 80,679,235 | 39,845 |
| Spyro: A Hero's Tail (2004) | 11,105,548 | 4,873 |
| Spyro: Attack of the Rhynocs (2003) | 421,285 | 706 |
| Spyro: Enter the Dragonfly (2002) | 9,482,434 | 4,660 |
| Spyro: Season of Ice (2001) | 750,271 | 1,182 |
| Spyro: Shadow Legacy (2005) | 362,977 | 322 |
| Spyro: Year of the Dragon (2000) | 56,377,817 | 32,726 |
| SQIJ! (1986) | 91,819 | 29 |
| Sqoon (1986) | 452,008 | 260 |
| SQR (2025) | 0 | 0 |
| Sqroma (2022) | 670 | 27 |
| Squab (2024) | 1,409 | 12 |
| Squad Assault: Second Wave (2005) | 4,495 | 10 |
| Squad Battles: Vietnam (2001) | 3,086 | 3 |
| SquadBlast (2023) | 47,075 | 73 |
| Squadron 51 (2022) | 135,317 | 89 |
| Squadron: Sky Guardians (2017) | 0 | 0 |
| Square Deal: The Game of Two Dimensional Poker (1990) | 20,643 | 16 |
| Square Fishing Builder (2024) | 0 | 0 |
| Square Inertia (2023) | 96 | 5 |
| Square Jump (2024) | 297 | 15 |
| Square Knight (2022) | 5,068 | 7 |
| Square Off (2009) | 1,262,142 | 79 |
| Square vs Triangles (2020) | 279 | 4 |
| Square's Tom Sawyer (1989) | 836,934 | 193 |
| Square: Trial And Error (2025) | 0 | 0 |
| SquareCells (2015) | 16,195 | 116 |
| Squareface (2016) | 80,437 | 81 |
| SquareMan (2022) | 934 | 2 |
| SquareMan-Boy (2022) | 830 | 12 |
| Squarena (2022) | 1,698 | 15 |
| Squares Rage (2020) | 84 | 1 |
| SquareWorld Unpixeled (2018) | 0 | 0 |
| Squarism (2017) | 8,679 | 74 |
| Squawky (2025) | 0 | 0 |
| Sqube Escape (2024) | 4,579 | 30 |
| Squeakers (2018) | 6,784,732 | 133 |
| Squeakross: Home Squeak Home (2025) | 39 | 8 |
| Squeeballs Party (2009) | 933,749 | 58 |
| Squeebing Up the Tower of Friendship (2023) | 101 | 5 |
| Squid Game: Unleashed (2024) | 3,103,196 | 1,242 |
| Squidgies Takeover (2019) | 3,443 | 5 |
| SQUIDS FROM SPACE (2017) | 1,696,907 | 89 |
| Squids Odyssey (2014) | 5,394,172 | 294 |
| Squiggle Football (2025) | 0 | 0 |
| Squigley (2024) | 0 | 0 |
| Squiigee (2024) | 0 | 0 |
| Squinky (2025) | 0 | 0 |
| Squirgle! (2008) | 1,699 | 7 |
| Squirm (2018) | 495,105 | 65 |
| SQUIRMISH: The Videogame of Brawling Beasties (2024) | 545 | 3 |
| Squirrel Jump (2019) | 3,152 | 6 |
| Squirrel King (1995) | 903,780 | 151 |
| Squirrel Legacy (2020) | 0 | 0 |
| Squirrel Legacy II: Children of the Nut (2024) | 0 | 0 |
| Squirrel with a Gun (2024) | 17,358,701 | 1,959 |
| Squirreled Away (2025) | 0 | 0 |
| Squirrelmageddon! (2021) | 37,058 | 30 |
| Squirrels are going nuts (2022) | 0 | 0 |
| Squirrels Forest Race (2024) | 84 | 3 |
| Squirreltopia (2015) | 89,709 | 78 |
| Squish 'em (1983) | 27,379 | 53 |
| Squish and the Corrupted Crystal (2017) | 568 | 5 |
| SquishCraft (2022) | 427,723 | 57 |
