| Spider-Man: The City That Never Sleeps (2018) | 10,749,840 | 4,008 |
| Spider-Man: The Sinister Six (1996) | 3,607,681 | 220 |
| Spider-Man: The Video Game (1991) | 4,202,007 | 1,354 |
| Spider-Man: Toxic City (2009) | 448,996 | 290 |
| Spider-Man: Web of Shadows (2008) | 350,287,525 | 15,487 |
| Spider: Rite of the Shrouded Moon (2015) | 2,134,636 | 308 |
| Spider: The Secret of Bryce Manor (2009) | 533,853 | 80 |
| Spider: The Video Game (1997) | 329,575 | 353 |
| Spiderbro 2 (2024) | 1 | 1 |
| Spiderdroid (1987) | 4,289 | 5 |
| SpiderHeck (2022) | 17,909,781 | 1,038 |
| Spidersaurs (2019) | 415,251 | 376 |
| SpiderSolitaire: BLACK (2018) | 178 | 2 |
| Spidertronic (1988) | 3,391 | 11 |
| The Spiderwick Chronicles (2008) | 6,941,213 | 777 |
| Spikair Volleyball (2022) | 156,542 | 59 |
| Spike (1983) | 8,155,421 | 868 |
| The Spike (2020) | 62,791,911 | 9,925 |
| Spike - A Love Story (2011) | 77,441 | 17 |
| Spike in Transilvania (1991) | 22,081 | 32 |
| Spike Match (2022) | 1,225 | 1 |
| Spike Volleyball (2019) | 19,600,816 | 6,636 |
| Spike's Peak (1983) | 52,235 | 52 |
| SpikeOut (1998) | 543,015 | 1,025 |
| Spikeout: Battle Street (2005) | 247,729 | 204 |
| Spikey's Bounce Around (2006) | 11,814 | 5 |
| Spikit (2016) | 0 | 0 |
| Spin Forward (2025) | 0 | 0 |
| Spin Hero (2024) | 258,382 | 163 |
| Spin Jam (2000) | 68,358 | 89 |
| Spin Rhythm XD (2019) | 1,540,802 | 2,211 |
| Spin Six (2010) | 2,516 | 45 |
| Spin the Beat (2017) | 21 | 1 |
| Spin the World (2021) | 2,165 | 10 |
| Spinch (2020) | 453,012 | 340 |
| Spindizzy (1986) | 51,093 | 63 |
| Spindizzy Worlds (1990) | 63,838 | 140 |
| Spindle (2023) | 678,957 | 291 |
| Spine Lasher (2026) | 0 | 0 |
| Spinmaster (1993) | 9,061,529 | 907 |
| Spinner Breaker (2021) | 0 | 0 |
| Spinnortality (2017) | 413,972 | 131 |
| Spinny Dungeon (2026) | 0 | 0 |
| Spinny's Journey (2020) | 11,046 | 22 |
| Spinochet (2025) | 0 | 0 |
| Spinout (2007) | 78,854 | 19 |
| Spinster (2025) | 0 | 0 |
| Spintires (2014) | 691,775,958 | 25,343 |
| Spintires: MudRunner (2017) | 515,764,475 | 33,648 |
| SpinZap (2020) | 0 | 1 |
| Spiral - Episode 1 (2022) | 11,606 | 12 |
| Spiral Clicker (2018) | 105,534 | 9 |
| Spiral Knights (2011) | 16,091,137 | 7,884 |
| Spiral Roll (2020) | 186,043,288 | 7,971 |
| The Spiral Scouts (2018) | 524,439 | 262 |
| Spiral Splatter (2017) | 0 | 0 |
| Spire Blast (2021) | 19,709 | 128 |
| Spire Horizon (2023) | 54,559 | 101 |
| Spire Horizon Online (2024) | 0 | 0 |
| Spire of Sorcery (2021) | 346,268 | 106 |
| Spire, Surge, and Sea (2025) | 0 | 0 |
| Spiriat (2022) | 510 | 11 |
| Spirit (2010) | 50,747 | 11 |
| Spirit Arena (2019) | 137,725 | 70 |
| Spirit Bounce (2021) | 652 | 9 |
| Spirit Camera: The Cursed Memoir (2012) | 852,977 | 124 |
| Spirit City: Lofi Sessions (2024) | 198,173 | 928 |
| The Spirit Engine 2 (2008) | 74,518 | 166 |
| The Spirit Engine DX (2026) | 143 | 4 |
| Spirit Guide Crucible (2017) | 0 | 0 |
| Spirit Hunter: Death Mark (2017) | 8,942,200 | 6,505 |
| Spirit Hunter: Death Mark II (2022) | 4,973,980 | 1,970 |
| Spirit Hunter: NG (2018) | 51,184,853 | 21,279 |
| Spirit Hunters: Infinite Horde (2023) | 1,190,629 | 1,495 |
| Spirit Interlude (2023) | 4,694 | 8 |
