| Spring It! (2018) | 463 | 3 |
| Spring Leaves No Flowers (2019) | 8,593 | 24 |
| Spring X Elixir (2023) | 685 | 2 |
| Springs of Ardor (2024) | 0 | 0 |
| Sprint 1 (1978) | 26,078 | 25 |
| Sprint 2 (1976) | 315,683 | 108 |
| Sprint 4 (1977) | 3,179 | 13 |
| Sprint 8 (1977) | 5,547 | 12 |
| Sprint Cars: Road to Knoxville (2006) | 113,433 | 95 |
| Sprint Master (1988) | 28,381 | 38 |
| Sprint Vector (2018) | 4,751,063 | 685 |
| Sprinter Monogatari: Mezase!! Ikkaku Senkin (1995) | 6,862 | 6 |
| Sprite Fantasia (2021) | 1,027,022 | 535 |
| Sprite Lamp (2014) | 0 | 0 |
| Sprite's Honor! (2024) | 49 | 2 |
| SpritePile (2019) | 0 | 0 |
| Spritify (2021) | 0 | 0 |
| Spritz the Happy Onion (2025) | 40 | 1 |
| Sprocket (2021) | 27,718,368 | 1,621 |
| Sproggiwood (2014) | 136,524 | 269 |
| Sproots (2020) | 67,111 | 16 |
| Sprout Valley (2023) | 70,564 | 188 |
| Sprung (2004) | 3,179,615 | 249 |
| Spryward (2022) | 35 | 3 |
| Spud's Adventure (1991) | 36,368 | 57 |
| Spuds Unearthed (2019) | 1,427,758 | 87 |
| SpunkStock: Music Festival (2022) | 65,262 | 12 |
| Spunky: Gangster Simulator (2023) | 0 | 0 |
| Sputnik (2021) | 2,323,322 | 94 |
| Spy 1 Lovecraftian (2024) | 0 | 0 |
| Spy Bot Chronicles (2009) | 12,549 | 15 |
| Spy Fiction (2003) | 745,602 | 285 |
| Spy Fox in Cheese Chase (1998) | 13,342 | 50 |
| Spy Fox in: Hold the Mustard (1999) | 6,776 | 56 |
| Spy Fox In: Hold the Mustard (2014) | 32,082 | 4 |
| Spy Games: Elevator Mission (2007) | 15,488 | 13 |
| Spy Hunter (1983) | 3,149,425 | 1,127 |
| Spy Hunter (2012) | 773,054 | 190 |
| Spy Hunter II (1987) | 18,845 | 29 |
| Spy Kids: All the Time in the World (2011) | 294,279 | 60 |
| Spy Mouse (2011) | 2,436,726 | 166 |
| Spy Muppets: License to Croak (2003) | 405,043 | 109 |
| Spy Robot: Gateways To Humanity (2022) | 309 | 4 |
| SPY RUMBLE (2022) | 737,731 | 368 |
| Spy Snatcher (1992) | 432 | 2 |
| Spy Tactics (2019) | 79,750 | 60 |
| Spy vs. Spy (1984) | 1,680,059 | 447 |
| Spy vs. Spy (2005) | 2,564,513 | 304 |
| Spy vs. Spy II: The Island Caper (1985) | 358,698 | 103 |
| Spy vs. Spy III: Arctic Antics (1986) | 80,139 | 86 |
| The Spy Who Loved Me (1990) | 9,112,485 | 495 |
| The Spy Who Shrunk Me! (2018) | 19,566,354 | 238 |
| Spy's Demise (1982) | 7,502 | 13 |
| Spyborgs (2009) | 470,436 | 333 |
| Spycat (1988) | 973 | 5 |
| Spycraft: The Great Game (1996) | 302,521 | 139 |
| Spyder (2020) | 15,735,804 | 437 |
| Spyglass Board Games (2007) | 3,431 | 4 |
| Spyhack (2020) | 4,133 | 18 |
| SpyHunter (2001) | 1,133,854 | 481 |
| SpyHunter 2 (2003) | 589,777 | 177 |
| SpyHunter: Nowhere to Run (2006) | 2,763,781 | 362 |
| SpyParty (2018) | 123,592,432 | 1,326 |
| Spyro 2: Ripto's Rage! (1999) | 62,022,590 | 46,814 |
| Spyro 2: Season of Flame (2002) | 332,090 | 820 |
| Spyro Orange: The Cortex Conspiracy (2004) | 1,804,138 | 614 |
| Spyro Reignited Trilogy (2018) | 229,864,583 | 114,440 |
| Spyro the Dragon (1998) | 80,610,454 | 39,777 |
| Spyro: A Hero's Tail (2004) | 11,103,482 | 4,860 |
| Spyro: Attack of the Rhynocs (2003) | 421,280 | 706 |
| Spyro: Enter the Dragonfly (2002) | 9,457,426 | 4,639 |
| Spyro: Season of Ice (2001) | 750,054 | 1,182 |
| Spyro: Shadow Legacy (2005) | 362,974 | 322 |
| Spyro: Year of the Dragon (2000) | 56,363,984 | 32,708 |
| SQIJ! (1986) | 91,819 | 29 |
