| Spencer's Spaghetti Quest (2025) | 19 | 1 |
| The Speris Legacy (1996) | 26,262 | 86 |
| Spewer (2009) | 25,056,347 | 127 |
| SPGP Super Polygon Grand Prix (2024) | 1,739 | 14 |
| Sphere - Flying Cities (2022) | 1,216,452 | 400 |
| Sphere 3 (2015) | 349,672 | 114 |
| Sphere Arena (2021) | 14 | 1 |
| Sphere Complex (2016) | 0 | 0 |
| Sphere Frustration (2017) | 132 | 4 |
| Sphere game colours (2024) | 0 | 0 |
| Sphere vs Gravity (2024) | 41 | 3 |
| Spherebuddie 64 (2026) | 4,403 | 2 |
| sphereFACE (2017) | 1,829 | 6 |
| Spheres of Chaos (1992) | 6,932 | 13 |
| Spheria's Familiar (2021) | 3,561 | 3 |
| Spherical (1989) | 949,714 | 165 |
| Spherical Worlds (1996) | 6,940 | 11 |
| Spheriums (2021) | 6,227 | 17 |
| SpHero (2024) | 806,172 | 43 |
| Sphinx and the Cursed Mummy (2003) | 3,977,093 | 2,665 |
| Spice and Wolf VR (2019) | 12,393,022 | 2,538 |
| Spice and Wolf: The Wind that Spans the Sea (2009) | 22,599 | 16 |
| Spice World (1998) | 2,590,723 | 126 |
| SpiceX (2024) | 0 | 0 |
| Spider and Web (1998) | 1,236 | 12 |
| Spider Fighter (1982) | 10,717,708 | 7,254 |
| Spider Fox (2024) | 567,503 | 105 |
| SPIDER HOTEL (2026) | 0 | 0 |
| Spider Solitaire (2020) | 1,293,242 | 798 |
| Spider Solitaire: Black (2018) | 316 | 4 |
| Spider-Man (1982) | 277,832 | 131 |
| Spider-Man (1995) | 1,170,248 | 298 |
| Spider-Man (2000) | 81,059,704 | 12,479 |
| Spider-Man (2002) | 86,602,908 | 7,308 |
| Spider-Man (2018) | 292,816,868 | 134,751 |
| Spider-Man 2 (2004) | 1,726,827,499 | 301,996 |
| Spider-Man 2: Enter Electro (2001) | 19,734,783 | 3,274 |
| Spider-Man 2: The Sinister Six (2001) | 2,054,718 | 155 |
| Spider-Man 3 (2007) | 1,558,675,325 | 28,008 |
| Spider-Man and the X-Men in Arcade's Revenge (1992) | 5,203,723 | 1,021 |
| Spider-Man and Venom: Maximum Carnage (1994) | 14,466,680 | 2,837 |
| Spider-Man Cartoon Maker (1995) | 715,615 | 25 |
| Spider-Man Unlimited (2014) | 252,022,276 | 6,655 |
| Spider-Man vs. The Kingpin (1991) | 10,215,453 | 1,734 |
| Spider-Man: Battle for New York (2006) | 379,681 | 288 |
| Spider-Man: Edge of Time (2011) | 130,579,178 | 5,630 |
| Spider-Man: Far From Home - Virtual Reality Experience (2019) | 154,973,087 | 872 |
| Spider-Man: Friend or Foe (2007) | 42,887,084 | 6,360 |
| Spider-Man: Homecoming - Virtual Reality Experience (2017) | 19,197,850 | 228 |
| Spider-Man: Mysterio's Menace (2001) | 869,266 | 387 |
| Spider-Man: Return of the Sinister Six (1992) | 3,441,079 | 885 |
| Spider-Man: Shattered Dimensions (2010) | 213,440,683 | 19,033 |
| Spider-Man: The Case of the Sinister Speller (2005) | 16,417 | 2 |
| Spider-Man: The City That Never Sleeps (2018) | 10,749,578 | 4,008 |
| Spider-Man: The Sinister Six (1996) | 3,607,681 | 220 |
| Spider-Man: The Video Game (1991) | 4,202,007 | 1,354 |
| Spider-Man: Toxic City (2009) | 448,996 | 290 |
| Spider-Man: Web of Shadows (2008) | 348,533,516 | 15,479 |
| Spider: Rite of the Shrouded Moon (2015) | 2,134,636 | 308 |
| Spider: The Secret of Bryce Manor (2009) | 533,853 | 80 |
| Spider: The Video Game (1997) | 329,575 | 353 |
| Spiderbro 2 (2024) | 1 | 1 |
| Spiderdroid (1987) | 4,289 | 5 |
| SpiderHeck (2022) | 17,909,781 | 1,038 |
| Spidersaurs (2019) | 415,251 | 376 |
| SpiderSolitaire: BLACK (2018) | 178 | 2 |
| Spidertronic (1988) | 3,391 | 11 |
| The Spiderwick Chronicles (2008) | 6,941,213 | 777 |
| Spikair Volleyball (2022) | 156,542 | 59 |
| Spike (1983) | 8,155,421 | 868 |
| The Spike (2020) | 62,785,883 | 9,920 |
| Spike - A Love Story (2011) | 77,441 | 17 |
| Spike in Transilvania (1991) | 22,081 | 32 |
| Spike Match (2022) | 1,225 | 1 |
| Spike Volleyball (2019) | 19,600,816 | 6,636 |
