| Seal of the Pharaoh (1994) | 13,474 | 38 |
| Seal Online (2003) | 26,033,101 | 25,020 |
| SEAL Team (1993) | 27,947,600 | 629 |
| Seal the Rift (2024) | 668 | 11 |
| Seal: Travelers of Destiny (2000) | 39,950 | 165 |
| Seal: WHAT the FUN (2024) | 685,816 | 166 |
| SealChain: Call of Blood (2026) | 25,505 | 58 |
| The Sealed Ampoule (2021) | 85,670 | 152 |
| Sealed Bite (2019) | 13,962 | 30 |
| Sealed Bite: Extended (2026) | 5,499 | 4 |
| Sealed in Wax (2024) | 4 | 1 |
| Sealer Assist (2020) | 0 | 0 |
| Seals of the Bygone (2020) | 7,059 | 25 |
| Seaman (1999) | 25,506,456 | 1,309 |
| Seaman 2 (2007) | 1,800,539 | 311 |
| Seaquest (1983) | 406,141 | 271 |
| seaQuest DSV (1994) | 720,729 | 155 |
| The Search for Amelia Earhart (2010) | 7,460 | 11 |
| The Search For Paradisus (2022) | 1,967 | 9 |
| Search for the Golden Dolphin (1999) | 449 | 2 |
| Search for the Titanic (1989) | 4,821 | 10 |
| Search of Galaxy (2022) | 1,523 | 7 |
| The Searchers of Legends : Origin (2019) | 802 | 5 |
| Searching For Rest (2024) | 91,537 | 21 |
| Sears: The Sky Frontier (2023) | 390 | 9 |
| Seas of Blood (1985) | 193,108 | 62 |
| Seaside Cafe Rush Hour (2024) | 4,525 | 5 |
| Season of Mystery: The Cherry Blossom Murders (2010) | 14,394 | 60 |
| Season of War (Alpha) (2019) | 217 | 2 |
| SEASON: A letter to the future (2023) | 2,260,815 | 2,218 |
| Seasons (2004) | 1,919,223 | 12 |
| Seasons After Fall (2016) | 4,118,519 | 4,212 |
| Seasons of the Samurai (2020) | 6,460 | 29 |
| Seasons of the Sorcerer (2022) | 35 | 2 |
| Seasons With Furry (2020) | 162 | 1 |
| Seasonspree (2024) | 2,193 | 20 |
| Seastalker (1984) | 1,349 | 13 |
| Seasteader (2017) | 735,711 | 7 |
| Seaweed Assault (2011) | 1,061 | 5 |
| Seawolf (2004) | 21,134 | 28 |
| SeaWorld Adventure Parks Tycoon (2003) | 36,808 | 29 |
| SeaWorld Adventure Parks Tycoon 2 (2005) | 2,073 | 2 |
| Sébastien Loeb Rally Evo (2016) | 7,643,114 | 3,711 |
| Sebil Engineering (2023) | 2,128,686 | 31 |
| Sebio (2024) | 0 | 0 |
| Seclusa (2025) | 13,679 | 17 |
| Seclusion (2025) | 244,105 | 97 |
| Second Chance Heroes (2014) | 105,341 | 47 |
| Second Earth (2014) | 1,339,286 | 195 |
| Second Extinction (2020) | 25,533,329 | 6,779 |
| Second Front: Germany Turns East (1990) | 515 | 1 |
| Second Galaxy (2019) | 2,927,367 | 867 |
| The second guest (2012) | 52,083 | 122 |
| Second Hand: Frankie's Revenge (2019) | 295,474 | 59 |
| Second Life (2003) | 93,269,383 | 17,099 |
| Second Person: Secret Laboratory (2022) | 101,011 | 2 |
| Second Rate Superheroes (2024) | 3,427 | 11 |
| Second Room (2024) | 135,142 | 22 |
| Second Samurai (1993) | 453,668 | 283 |
| Second Second (2019) | 48,059 | 32 |
| Second Sight (2004) | 2,238,185 | 1,579 |
| Second Sun (2025) | 781,850 | 147 |
| Second World: Air War S (2018) | 214 | 2 |
| Seconds in Space (2020) | 36,234 | 8 |
| Secret Agent (1992) | 1,626,018 | 295 |
| Secret Agent (2001) | 54,017 | 30 |
| Secret Agent Barbie (2001) | 2,142,173 | 386 |
| Secret Agent Barbie: Royal Jewels Mission (2002) | 31,317 | 62 |
| Secret Agent Clank (2008) | 6,989,534 | 2,959 |
| Secret Agent Files: Miami (2013) | 6,713 | 2 |
| Secret Agent Wizard Boy and the International Crime Syndicate (2025) | 3,261,672 | 251 |
| Secret Agent: The Escape (1996) | 37,210 | 16 |
| The Secret Atelier (2024) | 17,734 | 4 |
| Secret Camera (2023) | 14,314,735 | 105 |
| Secret City: London Calling (2018) | 601,850 | 118 |
