| SUB FOUR -the uncle (2018) | 0 | 0 |
| Sub Hunt (1982) | 7,293 | 44 |
| Sub Hunter (2008) | 14,351 | 44 |
| Sub Optimal Co. (2026) | 0 | 0 |
| Sub Rebellion (2002) | 159,239 | 158 |
| Sub Rosa (2021) | 22,379,229 | 480 |
| Sub Terra Draconis (2019) | 8 | 1 |
| Sub-Terrania (1994) | 82,026 | 221 |
| Sub-Verge (2025) | 0 | 0 |
| Subacuatic (2009) | 1,561 | 12 |
| Subaeria (2015) | 130,979 | 77 |
| SubaraCity (2015) | 79,758 | 57 |
| Subbuteo (1990) | 245,931 | 159 |
| Subcube (2019) | 485 | 5 |
| SubDivide (2020) | 499 | 6 |
| Subdivision Infinity DX (2017) | 226,436 | 229 |
| Subject 13 (2015) | 324,945 | 423 |
| Subject: Relictus (2021) | 0 | 0 |
| Sublevel Zero Redux (2015) | 585,909 | 305 |
| Subliminal Realms: Call of Atis (2017) | 18,096 | 59 |
| Subliminal Realms: The Masterpiece (2015) | 53,605 | 63 |
| Sublimity (2024) | 52,068 | 25 |
| Submachine 10: the Exit (2015) | 104,292 | 112 |
| Submachine 1: The Basement (2005) | 1,191,749 | 143 |
| Submachine 2: The Lighthouse (2006) | 139,139 | 67 |
| Submachine 3: The Loop (2006) | 15,352 | 52 |
| Submachine 4: The Lab (2007) | 119,307 | 65 |
| Submachine 5: The Root (2008) | 50,503 | 45 |
| Submachine 7: The Core (2010) | 372,803 | 41 |
| Submachine 8: The Plan (2012) | 120,362 | 38 |
| Submachine 9: The Temple (2014) | 193,630 | 56 |
| Submansion (2025) | 0 | 0 |
| Submarine (1978) | 28,471 | 21 |
| Submarine Attack (1990) | 145,289 | 241 |
| Submarine Commander (1982) | 4,293,255 | 148 |
| Submarine Survivor (2024) | 4,499 | 46 |
| Submarine Terror (2024) | 41,095 | 9 |
| Submarine Titans (2000) | 599,451 | 416 |
| SubmarineS (2002) | 16,795,786 | 159 |
| Submerged (2015) | 9,771,266 | 3,507 |
| Submerged: Hidden Depths (2020) | 1,701,304 | 3,589 |
| Submergent (2024) | 130 | 3 |
| SUBMERSIBLE (2025) | 5,274 | 5 |
| Subnautica (2018) | 3,824,472,564 | 400,547 |
| Subnautica 2 (2026) | 42,467,130 | 5,373 |
| Subnautica: Below Zero (2021) | 1,295,041,581 | 167,607 |
| SUBNET - Escape Room Adventure (2023) | 265,294 | 47 |
| Suborbital (2024) | 29,945 | 6 |
| SubRoc-3D (1982) | 35,354 | 36 |
| subROV : Underwater Discoveries (2022) | 29,416 | 51 |
| Subside (2024) | 484,009 | 200 |
| Subsideria (2018) | 20,132 | 5 |
| Subsistence (2016) | 58,387,386 | 51,272 |
| SubSpace (1997) | 801,572 | 326 |
| Subspace Continuum (2015) | 145 | 2 |
| Subspace Discovery (2023) | 399 | 5 |
| Substation (1995) | 209,956 | 73 |
| Subsunk (1985) | 1,462 | 7 |
| Subsurface Circular (2017) | 116,225 | 232 |
| Subtension (2023) | 9,810 | 1 |
| SubterAlien Rescue (2023) | 0 | 0 |
| Subterfuge (2015) | 204,163 | 79 |
| Subterrain (2016) | 1,075,134 | 1,337 |
| Subterrain: Mines of Titan (2024) | 359,809 | 305 |
| Subterranauts (2024) | 58,199 | 9 |
| Subterranean Animism (2008) | 61,727,673 | 5,374 |
| Subterranean Starfield (2013) | 1,288 | 18 |
| Subterror (2024) | 1,486,182 | 229 |
| Subtrade (1992) | 3,249 | 6 |
| Subverse (2024) | 7,226,170 | 450 |
| Subwar 2050 (1993) | 312,329 | 64 |
| Subway Scramble (2005) | 2,836 | 6 |
| Subway Surfers (2012) | 8,366,520,386 | 701,582 |
| Subway Vigilante (1989) | 45,440 | 18 |
| SubwaySim 2 (2025) | 21,121 | 31 |
